牙源性颗粒细胞瘤：1例病例报告和文献复习

doi:10.24920/004159

摘要/Abstract

摘要：

中央颗粒细胞牙源性肿瘤（central granular cell odontogenic tumors，CGCOTs）是一种罕见的、良性、生长缓慢的牙源性肿瘤。由于不能确定其组织来源，CGCOTs仍未被作为一个独立的类别纳入WHO(2017)牙源性肿瘤分类。我们报道了1例CGCOT新发病例，患者为39岁白人女性，肿瘤位于上颌前区右侧。免疫组化染色显示：颗粒细胞表达CD68和vimentin阳性，表达S-100蛋白阴性。此外，我们通过检索PubMed、Google Scholar和Scopus数据库，总结了51例CGCOT患者的临床病理特征。结果显示：28.6%的颗粒细胞呈vimentin和CD68阳性，所有牙源性上皮细胞呈角蛋白阳性。这些发现进一步证实了颗粒细胞的间质起源和上皮细胞的牙源性性质。

关键词: 中央颗粒细胞牙源性肿瘤')">

中央颗粒细胞牙源性肿瘤, 中央颗粒细胞牙源性纤维瘤, 牙源性肿瘤, 颗粒细胞成釉纤维瘤, 组织发生

Abstract:

Central granular cell odontogenic tumors (CGCOTs) are rare, benign, slowly growing odontogenic neoplasms. Due to their uncertain histogenesis, CGCOTs are still not included as a distinct entity in the WHO classification (2017) of odontogenic tumors. We report a case of CGCOT involving the right side of maxillary anterior region of a 39-year-old white female. Immunohistochemical staining showed that granular cells positively expressed CD68 and vimentin, and negatively expressed S-100 protein. Meanwhile, we searched PubMed, Google Scholar, and Scopus databases to summary the clinico-pathological features of 51 reported cases of CGCOT. The results showed that the granular cells of 28.6% cases were immunopositive for vimentin and CD68, and odontogenic epithelial cells were positive immunoreactivity for cytokeratin. These findings reinforced the mesenchymal origin of granular cells and the odontogenic nature of epithelium islands.

Key words: central granular cell odontogenic tumor, central granular cell odontogenic fibroma, odontogenic tumor, granular cell ameloblastic fibroma, histogenesis

Fatemeh Mashhadiabbas, Sanaz GholamiToghchi, Roohollah Safarpour. Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report[J].Chinese Medical Sciences Journal, 2023, 38(2): 138-146.

图/表 5

References	Year of publication	Age (yrs)	Gender	Location	Radiographic features	Treatment	Follow-up
Werthemann^[1]	1950	39	Male	Left mandibular premolar/molar	NS	NS	NS
Couch et al.^[2]	1962	55	Femle	Left mandibular second molar	Radiolucent lesion with loculated borders	Conservative removal of the lesion with tooth extraction	NR 8 months
Couch et al.^[2]	1962	59	Female	Left mandibular canine	Loculated radiolucency with focal densities	Removal of tumor	NR 27 months
Waldron et al.^[25]	1963	60	Female	Left mandibular canine	2.0 cm radiolucent lesion	Removal of tumor	NR 29 months
Waldron et al.^[25]	1963	53	Female	Left mandibular molar	2.0-3.0 cm cystic radiolucency, displacment of teeth	Removal of the mass with tooth extraction	NR 3 months
Gorlin et al.^[26]	1970	50	Female	Mandibular molar region	NS	Curettage	NS
Dalforno et al.^[3]	1970	57	NS	Left mandibular molar	NS	Curettage	NR 6 months
White et al.^[4]	1978	50	Female	Mandibular canine area	Radiolucency	Curettage	NR 6 months
White et al.^[4]	1978	50	Female	Mandibular posterior area	Radiolucency	Curettage	NR 7 years
White et al.^[4]	1978	55	Female	Maxillary premolar	Radiolucency	Surgical excision	NR 3 years
White et al.^[4]	1978	65	Female	Mandibular premolar/molar	Radiolucency	Surgical excision	NR 2 years
Regezi et al.^[24]	1978	29	Female	Maxilla	NS	NS	NS
Regezi et al.^[27]	1978	16	Male	Mandible	NS	NS	NS
Vincent et al.^[5]	1987	51	Female	Right mandibular premolar/molar	4-2 cm radiolucency with sclerotic border	Conservative removal of the mass	NS
Vincent et al.^[5]	1987	27	Male	Right mandibular second premolar/first molar	1.5 cm unicystic radiolucency with sclerotic borders	Surgical excision	NR 24 months
Shiro et al.^[6]	1989	45	Female	Left mandibular premolars	0.7-0.4 cm unicystic radiolucency	Surgical excision	NR 4 years
Mirchandani et al.^[7]	1989	33	Female	Mandible	Radiolucency	NS	NS
Ruhl et al.^[28]	1989	22	Male	Left maxillary first and second molars	4.5 cm with slight displacement of teeth	Complete resection	NS
Chen^[29]	1991	50	Female	Right mandibular canine	1.0-0.8 cm radiolucency	NS	NS
Chen^[29]	1991	45	Female	Left mandibular premolar/molar	5.0-3.0 cm radiolucency	NS	NS
Chen^[29]	1991	64	Female	Left mandibular canine/premolar	3.0-2.0 cm radiolucency	NS	NS
Chen^[29]	1991	77	Female	Left mandibular premolars	0.5-0.5 cm radiolucency	NS	NS
Yih et al.^[34]	1995	66	Female	Left mandibular second premolar	0.5-0.5 cm unilocular radiolucency	Curettage	NR 6 months
Gesek et al.^[8]	1995	62	Female	Left mandibular second premolar	Multilocular, well-circumscribed radiolucency	Curettage	NR 12 months
Machado de Sousa et al.^[39]	1998	19	Female	Right maxillary premolar/molar	Well-delineated multilocular radiolucency	Surgical excision	NR 24 months
Machado de Sousa et al.^[35]	1998	25	Male	Right maxillary premolar/molar	8.0 cm radiopaque lesion	Surgical excision	NR 120 months
Ardekian et al.^[11]	1998	63	Male	Right maxillary premolar/molar	Well-defined radiolucency with sclerotic border	Curettage Teeth extraction	NR 48 months
Matsumoto et al.^[30]	2000	24	Male	Left mandibular premolars	Well-demarcated radiolucent lesion	Enucleation with teeth extraction	NR 1.5 years
Brannon et al.^[12]	2002	36	Female	Mandibular canine/ premolar	NS	NS	NS
Brannon et al.^[12]	2002	50	Female	Jaw	NS	NS	NS
Brannon et al.^[12]	2002	32	Female	Mandibular canine/ premolar	Multilocular radiolucency with sclerotic border	Teeth extraction with surgical excision	NR 180 months
Brannon et al.^[12]	2002	19	Female	Left maxillary first premolar/first molar	Unicystic radiolucency enveloping roots of second premolar	Curettage	Recurrence 156 months
Brannon et al.^[12]	2002	48	Male	Right side of maxilla	NS	NS	NS
Calvo et al.^[36]	2002	61	Male	Anterior region of maxilla	Radiolucency with resorption of anterior teeth	NS	NS
Meer et al.^[13]	2004	65	Female	Left mandibular first premolar/second molar	Irregular radiolucency from first premolar to second molar	Surgical excision	NR 12 months
Reichart et al.^[41]	2006	46	Female	Right mandibular premolar/molar	Multilocular radiolucent lesion	Surgical excision with reconstruction	NR 2 yrs.
Gomes et al.^[9]	2006	20	Female	Left mandibular premolars/molars	An intra-osseous mixed lesion, 5 cm	Enucleation	NR 7 months
Kim et al.^[14]	2006	33	Male	Right maxillary premolar/first molar	Well-defined unilocular radiolucency	Enucleation with tooth extraction	NR 23 months
Mesquita et al.^[15]	2009	20	Female	Left mandibular second premolar/second molar	Well-defined radiolucency with foci of calcifications	Complete resection of tumor	NR 4 years
Lotay et al.^[38]	2010	28	Female	Right maxillary premolar	1.5-2.5 cm well-defined mixed lesion	Enucleation and curettage	NS
Silva et al.^[16]	2012	41	Female	Left side of maxilla	Well-defined mixed lesion	Surgical excision	NR 2 years
Sarode et al.^[17]	2013	25	Female	Right side of mandible crossing the midline	Well-demarcated multilocular radiolucent lesion	Enucleation and curettage	NR 2 years
Cheng et al.^[18]	2013	52	Female	Right mandibular premolars	Well-defined mixed lesion	Enucleation	NR 3 months
Chiang et al.^[19]	2014	69	Male	Ramus of left mandible	Well-demarcated radiolucent lesion	Surgical excision	NR 2 months
Anbiaee et al.^[20]	2014	16	Female	Left mandibular angle	Multilocular mixed lesion, 3 cm × 5 cm	Surgical resection with mandibular reconstruction	NR 2 years
Lee et al.^[21]	2014	19	Male	Left mandibular third molar	Enlarged dental follicle	Enucleation with tooth extraction	NS
Fletcher et al.^[31]	2015	19	Female	Right mandibular second premolar/molars	Unilocular radiolucent lesion	Curettage	NR 24 months
Vennamaneni et al.^[32]	2016	38	Male	Right mandibular premolars/first molar	Well-defined unilocular radiolucent lesion	Enucleation	NR NS
Madan et al.^[22]	2016	73	Male	Anterior area of mandible	Multilocular radiolucent lesion	Segmental resection	NR 9 months
Atarbashi- Moghadam et al.^[33]	2019	57	Female	Left mandibular premolars/first molar	Well defined radiolucent lesion	Enucleation	NR 12 months
Koth et al.^[23]	2021	42	Femlae	Left maxillary anterior region	Unilocular radiolucency	Surgical removal	NR 16 months

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