特应性皮炎伴双眼视网膜脱离及视网膜血管炎1例

doi:10.24920/004321

Chinese Medical Sciences Journal ›› 2024, Vol. 39 ›› Issue (1): 74-78.doi: 10.24920/004321

• 病例报告 • 上一篇

特应性皮炎伴双眼视网膜脱离及视网膜血管炎1例

程世瑜^1,²,王造文¹,戴荣平^1,^2,^*()

¹中国医学科学院北京协和医学院北京协和医院眼科，北京 100730，中国
²中国医学科学院北京协和医学院眼底病重点实验室，北京 100730，中国

收稿日期:2023-11-23 接受日期:2024-01-23 出版日期:2024-03-31 发布日期:2024-02-29
通讯作者: 戴荣平

Atopic Dermatitis Associated Retinal Detachment and Retinal Vasculitis: A Case Report

Shi-Yu Cheng^1,²,Zao-Wen Wang¹,Rong-Ping Dai^1,^2,^*()

¹Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
²Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Received:2023-11-23 Accepted:2024-01-23 Published:2024-03-31 Online:2024-02-29
Contact: * E-mail: derricka@sina.com

摘要/Abstract

摘要：

特应性皮炎可伴有多种眼部并发症，如结膜炎、角膜炎、白内障和视网膜脱离等。我们报道了1例因双眼视网膜脱离及白内障就诊于眼科的21岁中国男性患者。该患者8年前诊断为特应性皮炎，并接受氯雷他定和吡美莫司治疗。我们为该患者进行了双眼白内障摘除术、右眼巩膜外加压术，以及左眼玻璃体切除及硅油填充术。术后随访期间，患者的特应性皮炎加重，眼底荧光素血管造影结果显示双眼视网膜血管广泛渗漏和左眼黄斑水肿。随后患者至皮肤科接受4个月规律的度普利尤单抗治疗，左眼黄斑水肿好转，术后3年眼部情况一直保持稳定。

关键词: 特应性皮炎, 视网膜脱离, 视网膜血管炎

Abstract:

Atopic dermatitis is usually associated with various ocular complications. We report a 21-year-old Chinese male who presented to our ophthalmology clinic with bilateral retinal detachment and cataracts. The patient had a clear medical history of atopic dermatitis, which had been diagnosed eight years earlier and had been treated with loratadine and pimecrolimus. Cataract surgery was performed for both eyes, combined with scleral buckling for the right eye and pars plana vitrectomy for the left eye. During postoperative follow-up, fundus fluorescein angiography showed retinal vasculitis in both eyes and macular edema in the left eye, which coincided with an exacerbation of atopic dermatitis. Macular edema improved after four months of regular dupilumab treatment in the dermatology department. The ocular condition remained stable three years postoperatively.

Key words: atopic dermatitis, retinal detachment, retinal vasculitis

Shi-Yu Cheng, Zao-Wen Wang, Rong-Ping Dai. Atopic Dermatitis Associated Retinal Detachment and Retinal Vasculitis: A Case Report[J].Chinese Medical Sciences Journal, 2024, 39(1): 74-78.

图/表 2

参考文献 30.

1.	Ständer S. Atopic dermatitis. N Engl J Med 2021; 384(12):1136-43. doi: 10.1056/NEJMra2023911.
2.	Ni X, Xu Y, Wang W, et al. IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation. Nat Immunol 2022 23(11):1577-87. doi: 10.1038/s41590-022-01339-3.
3.	Huang IH, Chung WH, Wu PC, et al. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review. Front Immunol 2022; 13:1068260. doi: 10.3389/fimmu.2022.1068260.
4.	Darlenski R, Kazandjieva J, Hristakieva E, et al. Atopic dermatitis as a systemic disease. Clin Dermatol 2014; 32(3):409-13. doi: 10.1016/j.clindermatol.2013.11.007. pmid: 24767188
5.	Ravn NH, Ahmadzay ZF, Christensen TA, et al. Bidirectional association between atopic dermatitis, conjunctivitis, and other ocular surface diseases: a systematic review and meta-analysis. J Am Acad Dermatol 2021; 85(2):453-61. doi: 10.1016/j.jaad.2020.11.037.
6.	Pietruszyńska M, Zawadzka-Krajewska A, Duda P, et al. Ophthalmic manifestations of atopic dermatitis. Postepy Dermatol Alergol 2020; 37(2):174-9. doi: 10.5114/ada.2018.79445.
7.	Sasoh M, Mizutani H, Matsubara H, et al. Incidence of retinal detachment associated with atopic dermatitis in Japan: review of cases from 1992 to 2011. Clin Ophthalmol 2015; 9:1129-34. doi: 10.2147/opth.S85020.
8.	Yamamoto K, Wakabayashi Y, Kawakami S, et al. Recent trends of ocular complications in patients with atopic dermatitis. Jpn J Ophthalmol 2019; 63(5):410-6. doi: 10.1007/s10384-019-00678-3. pmid: 31243592
9.	Hida T, Tano Y, Okinami S, et al. Multicenter retrospective study of retinal detachment associated with atopic dermatitis. Jpn J Ophthalmol 2000; 44(4):407-18. doi: 10.1016/s0021-5155(00)00174-x. pmid: 10974298
10.	Takahashi M, Suzuma K, Inaba I, et al. Retinal detachment associated with atopic dermatitis. Br J Ophthalmol 1996; 80(1):54-7. doi: 10.1136/bjo.80.1.54.
11.	Fong AH, Yip PP, Kwok TY, et al. A 12-year review on the aetiology and surgical outcomes of paediatric rhegmatogenous retinal detachments in Hong Kong. Eye (Lond) 2016; 30(3):355-61. doi: 10.1038/eye.2015.212.
12.	Chang PY, Yang CM, Yang CH, et al. Clinical characteristics and surgical outcomes of pediatric rhegmatogenous retinal detachment in Taiwan. Am J Ophthalmol 2005; 139(6):1067-72. doi: 10.1016/j.ajo.2005.01.027.
13.	Choi M, Byun SJ, Lee DH, et al. The association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study. Eye (Lond) 2020; 34(10):1909-15. doi: 10.1038/s41433-020-0816-1.
14.	Lee Y, Park WK, Kim RY, et al. Characteristics of retinal detachment associated with atopic dermatitis. BMC Ophthalmol 2021; 21(1): 359. doi: 10.1186/s12886-021-02135-7.
15.	Azuma N, Hida T, Katsura H, et al. Retrospective survey of surgical outcomes on rhegmatogenous retinal detachments associated with atopic dermatitis. Arch Ophthalmol 1996; 114(3):281-5. doi: 10.1001/archopht.1996.01100130277008.
16.	Gnana Jothi V, McGimpsey S, Sharkey JA, et al. Retinal detachment repair and cataract surgery in patients with atopic dermatitis. Eye (Lond) 2017; 31(9):1296-301. doi: 10.1038/eye.2017.151.
17.	Oka C, Ideta H, Nagasaki H, et al. Retinal detachment with atopic dermatitis similar to traumatic retinal detachment. Ophthalmology 1994; 101(6):1050-4. doi: 10.1016/s0161-6420(94)31219-x. pmid: 8008346
18.	Tan L, Teo L, Lee SY. Case series: bilateral rhegmatogenous retinal detachments in atopic dermatitis. Optom Vis Sci 2018; 95(7):621-4. doi: 10.1097/opx.0000000000001244. pmid: 29957736
19.	Matsuo T, Shiraga F, Matsuo N. Intraoperative observation of the vitreous base in patients with atopic dermatitis and retinal detachment. Retina 1995; 15(4):286-90. doi: 10.1097/00006982-199515040-00003.
20.	Coles RS, Laval J. Retinal detachments occurring in cataract associated with neurodermatitis. AMA Arch Ophthalmol 1952; 48(1):30-9. doi: 10.1001/archopht.1952.00920010033004. pmid: 14932558
21.	Yoshida S, Sasoh M, Arima M, et al. Ultrasound biomicroscopic view of detachment of the ciliary epithelium in retinal detachment with atopic dermatitis. Ophthalmology 1997; 104(2):283-7. doi: 10.1016/s0161-6420(97)30323-6. pmid: 9052633
22.	Iijima Y, Wagai K, Matsuura Y, et al. Retinal detachment with breaks in the pars plicata of the ciliary body. Am J Ophthalmol 1989; 108(4):349-55. doi: 10.1016/s0002-9394(14)73299-4. pmid: 2801853
23.	Rønnstad ATM, Hansen PM, Halling AS, et al. Factors associated with ocular surface disease and severity in adults with atopic dermatitis: a nationwide survey. J Eur Acad Dermatol Venereol 2022; 36(4):592-601. doi: 10.1111/jdv.17832.
24.	Seo Y, Han J, Kim MJ, et al. Comprehensive evaluation of ocular complications in atopic dermatitis: insights from a contemporary cohort study in Korean population. Int J Dermatol 2023; Dec 21. doi: 10.1111/ijd.16983.Onlineaheadofprint.
25.	Fishbein AB, Silverberg JI, Wilson EJ, et al. Update on atopic dermatitis: diagnosis, severity assessment, and treatment selection. J Allergy Clin Immunol Pract 2020; 8(1):91-101. doi: 10.1016/j.jaip.2019.06.044. pmid: 31474543
26.	Cork MJ, Thaçi D, Eichenfield LF, et al. Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase Ⅱa open-label trial and subsequent phase Ⅲ open-label extension. Br J Dermatol 2020; 182(1):85-96. doi: 10.1111/bjd.18476.
27.	Bieber T. Atopic dermatitis: an expanding therapeutic pipeline for a complex disease. Nat Rev Drug Discov 2022; 21(1):21-40. doi: 10.1038/s41573-021-00266-6.
28.	Ungar B, Pavel AB, Robson PM, et al. A preliminary (18)F-FDG-PET/MRI study shows increased vascular inflammation in moderate-to-severe atopic dermatitis. J Allergy Clin Immunol Pract 2020; 8(10):3500-6. doi: 10.1016/j.jaip.2020.07.018.
29.	Lee KH, Chung YR, Park HR, et al. Surgical outcomes of vitrectomy for primary treatment of rhegmatogenous retinal detachment in patients with atopic dermatitis. Korean J Ophthalmol 2023; 37(2):105-11. doi: 10.3341/kjo.2022.0103. pmid: 36758537
30.	Cho AR, Yoon YH. Adjunctive dexamethasone implant in patients with atopic dermatitis and retinal detachment undergoing vitrectomy and silicone oil tamponade: an interventional case series. BMC Ophthalmol 2019; 19(1): 86. doi: 10.1186/s12886-019-1094-1.

优先出版

当期目次

过刊浏览

虚拟专题

作者中心

评阅者中心

特应性皮炎伴双眼视网膜脱离及视网膜血管炎1例

Atopic Dermatitis Associated Retinal Detachment and Retinal Vasculitis: A Case Report

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 2

参考文献 30.

相关文章 0

Metrics

推荐阅读 10