Chinese Medical Sciences Journal ›› 2012, Vol. 27 ›› Issue (2): 88-91.

• Original Article • 上一篇    下一篇

Correlations Between Serum Uric Acid Level and Disease Activity, Intrathecal Inflammation Reactivity in Patients with Multiple Sclerosis

Cai-yan Liu1, Yan Xu1, Li-ying Cui1*, Bin Peng1, Li-zhen Zhong2, Xing-wang Chen3, and Jian-ming Wang1   

  1. 1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of Neurology, Dalian Central Hospital, Dalian 116033, China
    3Department of Neurology, Shandong Traffic Hospital, Jinan 250031, China
  • 收稿日期:2012-07-05 修回日期:2012-07-05 出版日期:2012-07-05 发布日期:2012-07-05
  • 作者简介:*Corresponding author Tel: 86-10-65296371, E-mail: pumchcly@yahoo.com.cn

Correlations Between Serum Uric Acid Level and Disease Activity, Intrathecal Inflammation Reactivity in Patients with Multiple Sclerosis

Cai-yan Liu1, Yan Xu1, Li-ying Cui1*, Bin Peng1, Li-zhen Zhong2, Xing-wang Chen3, and Jian-ming Wang1   

  1. 1Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
    2Department of Neurology, Dalian Central Hospital, Dalian 116033, China
    3Department of Neurology, Shandong Traffic Hospital, Jinan 250031, China
  • Received:2012-07-05 Revised:2012-07-05 Online:2012-07-05 Published:2012-07-05

摘要: Objective To explore the correlations between serum uric acid (UA) levels and the clinical and cerebrospinal fluid (CSF) parameters of multiple sclerosis (MS).
Methods The medical reports of 47 MS patients admitted to Peking Union Medical College Hospital during 2008 and 2010 were reviewed. And 49 age- and gender-matched cerebral infarction patients were enrolled as control. The mean serum UA level of the MS patients was compared with that of the control group. The correlations between the UA levels and the clinical parameters including gender, disease duration, relapse rate, and disease disabilities as assessed by the Expanded Disability Status Scale score, were explored. Forty-one patients had CSF examinations. The correlations between the UA levels and the CSF parameters reflecting inflammation and tissue damage, including CSF protein, white blood cell count, oligoclonal band, 24-hour IgG index, and myelin basic protein, were also investigated.
Results The mean serum UA level in the MS patients was lower than that in the control group (247.75 ± 52.59 µmol/L vs. 277.94 ± 74.33 µmol/L, P=0.025) and inversely correlated with the relapse rate (P=0.049). MS patients with lower serum UA levels tended to have higher white blood cell counts and myelin basic protein level. But there was no correlation between CSF protein levels (r=0.165, P=0.273), white blood cell counts (r=-0.051, P=0.732), IgG index (r =0. 045, P=0.802), or myelin basic protein level (r =-0.248, P=0.145) and the serum UA level, respectively. Conclusion In MS patients, UA levels might partly reflect the extent of disability and inflammation.

关键词: uric acid, multiple sclerosis, relapse rate, cerebrospinal fluid

Abstract: Objective To explore the correlations between serum uric acid (UA) levels and the clinical and cerebrospinal fluid (CSF) parameters of multiple sclerosis (MS).
Methods The medical reports of 47 MS patients admitted to Peking Union Medical College Hospital during 2008 and 2010 were reviewed. And 49 age- and gender-matched cerebral infarction patients were enrolled as control. The mean serum UA level of the MS patients was compared with that of the control group. The correlations between the UA levels and the clinical parameters including gender, disease duration, relapse rate, and disease disabilities as assessed by the Expanded Disability Status Scale score, were explored. Forty-one patients had CSF examinations. The correlations between the UA levels and the CSF parameters reflecting inflammation and tissue damage, including CSF protein, white blood cell count, oligoclonal band, 24-hour IgG index, and myelin basic protein, were also investigated.
Results The mean serum UA level in the MS patients was lower than that in the control group (247.75 ± 52.59 µmol/L vs. 277.94 ± 74.33 µmol/L, P=0.025) and inversely correlated with the relapse rate (P=0.049). MS patients with lower serum UA levels tended to have higher white blood cell counts and myelin basic protein level. But there was no correlation between CSF protein levels (r=0.165, P=0.273), white blood cell counts (r=-0.051, P=0.732), IgG index (r =0. 045, P=0.802), or myelin basic protein level (r =-0.248, P=0.145) and the serum UA level, respectively. Conclusion In MS patients, UA levels might partly reflect the extent of disability and inflammation.

Key words: uric acid, multiple sclerosis, relapse rate, cerebrospinal fluid

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