Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (4): 323-332.doi: 10.24920/004007

• 综述 • 上一篇    下一篇


黄皓1,4,刘朝宗2,易腾3,Maryam Tamaddon2,苑姗姗5,史震云4,*(),刘子钰1,2,3,*()   

  1. 1北京航空航天大学工程医学院,北京 100191
    2英国伦敦大学学院外科与介入科学系,英国伦敦斯坦莫尔市 英国皇家国家骨科医院,伦敦HA7 4LP,英国
    3国防科技创新研究院,北京 100071
    4北京航空航天大学机械工程及自动化学院,北京 100191
    5青岛市立医院心内科,山东青岛 266071
  • 收稿日期:2021-09-27 出版日期:2021-12-31 发布日期:2021-12-21
  • 通讯作者: 史震云,刘子钰;

Substitution for In Vitro and In Vivo Tests: Computational Models from Cell Attachment to Tissue Regeneration

Hao Huang1,4,Chaozong Liu2,Teng Yi3,Maryam Tamaddon2,Shanshan Yuan5,Zhenyun Shi4,*(),Ziyu Liu1,2,3,*()   

  1. 1School of Engineering Medicine, Beihang University, 100191 Beijing, China
    2Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, London, UK
    3National Institude of Defense Science and Technology, Beijing 100071, China
    4School of Mechanical Engineering and Automation, Beihang University, 100191 Beijing, China
    5Department of Cardiology, Qingdao Municipal Hospital, Qingdao, Shandong 266071, China
  • Received:2021-09-27 Published:2021-12-31 Online:2021-12-21
  • Contact: Zhenyun Shi,Ziyu Liu;



关键词: 组织工程, 支架, 计算机辅助设计, 计算流体力学, 有限元模型


To get an optimal product of orthopaedic implant or regenerative medicine needs to follow trial-and-error analyses to investigate suitable product’s material, structure, mechanical properites etc. The whole process from in vivo tests to clinical trials is expensive and time-consuming. Computational model is seen as a useful analysis tool to make the product development. A series of models for simulating tissue engineering process from cell attachment to tissue regeneration are reviewed. The challenging is that models for simulating tissue engineering processes are developed separately. From cell to tissue regeneration, it would go through blood injection after moving out the defect; to cell disperse and attach on the scaffold; to proliferation, migration and differentiation; and to the final part—becoming mature tissues. This paper reviewed models that related to tissue engineering process, aiming to provide an opportunity for researchers to develop a mature model for whole tissue engineering process. This article focuses on the model analysis methods of cell adhesion, nutrient transport and cell proliferation, differentiation and migration in tissue engineering. In cell adhesion model, one of the most accurate method is to use discrete phase model to govern cell movement and use Stanton-Rutland model for simulating cell attachment. As for nutrient transport model, numerical model coupling with volume of fluid model and species transport model together is suitable for predicting nutrient transport process. For cell proliferation, differentiation and migration, finite element method with random-walk algorithm is one the most advanced way to simulate these processes. Most of the model analysis methods require further experiments to verify the accuracy and effectiveness. Due to the lack of technology to detect the rate of nutrient diffusion, there are especially few researches on model analysis methods in the area of blood coagulation. Therefore, there is still a lot of work to be done in the research of the whole process model method of tissue engineering. In the future, the numerical model would be seen as an optimal way to investigate tissue engineering products bioperformance and also enable to optimize the parameters and material types of the tissue engineering products.

Key words: tissue engineering, scaffold, computer aided design, computational fluid dynamics, finite element models

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