Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (1): 23-30.doi: 10.1016/S1001-9294(16)30018-9

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Establish Albumin-creatinine Ratio Reference Valueof Adults in the Rural Area of Hebei Province

Qiao-jing Liang1, Wen Huang1*, Guo-juan Zhang1, Ning-li Wang2, *   

  1. 1Department of Nephrology,
    2Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2015-07-20 Online:2016-03-20 Published:2016-03-20
  • Contact: Wen Huang, E-mail: 25911412@163.com, Ning-li Wang, E-mail: wningli@vip.163.com
  • Supported by:

    △Supported by the National Basic Research Program of China (973 Program) (2007CB512201), the Program of Health Policy for blindness prevention from China, the Key Technologies R&D Program (2006-10903) from the Science and Technology Bureau of Handan City, Hebei Province, China, a program from Beijing Tongren Hospital, and key discipline fund of Health Bureau, Handan City, Hebei Province, China

Abstract:

Objective To establish albumin-creatinine ratio (ACR) reference value of the rural population in Hebei province.Methods This study enrolled 5154 participants. By excluding subjects with hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, kidney diseases, and overweight condition, as well as those with an estimated glomerular filtration rate (eGFR)<60 ml/(min·1.73 m2), apparently healthy subjects (1168) were selected. Urine albumin was measured by using the immunoturbidimetic method, serum creatinine was measured by using Jaffe’s kinetic method on a morning spot-urine sample, and ACR was calculated. The 95th percentile of ACR in the healthy subjects was used as the normal upper limit.Results The normal upper limit of ACR was 28.71 mg/g (3.25 mg/mmol) for males and 31.85 mg/g (3.60 mg/mmol) for females. Based on this ACR reference value, the age-gender standardized prevalence of albuminuria in the rural areas of Hebei province was 12.9%.Conclusion The ACR reference value in the rural of Hebei province is higher than that of the Western population.

Key words: albumin-creatinine ratio, albuminuria, chronic kidney disease

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