Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (3): 275-281.doi: 10.24920/003936

• Review • Previous Articles     Next Articles

Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Nana Zhang1, Zijian Li2, *(), Haibo Zhu3, *()   

  1. 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China
    2Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100050, China
    3State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
  • Received:2021-05-16 Accepted:2022-01-23 Published:2022-09-30 Online:2022-06-26
  • Contact: Zijian Li,Haibo Zhu;

Myocardial perfusion imaging (MPI) is valuable for the diagnosis, prognosis, and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However, these agents have contraindications and may cause adverse effects in some patients. Thus, other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI, including its mechanism of action, stress protocol, efficacy, and safety.

Key words: coronary artery disease, higenamine, myocardial perfusion imaging, stress agent


Copyright © 2021 Chinese Academy of Medical Sciences.  京公安备110402430088  京ICP备06002729号-1  Powered by Magtech.

Supervised by National Health Commission of the People's Republic of China

9 Dongdan Santiao, Dongcheng district, Beijing, 100730 China

Tel: 86-10-65105897  Fax:86-10-65133074 


Copyright © 2018 Chinese Academy of Medical Sciences

All right reserved.

京公安备110402430088  京ICP备06002729号-1