Chinese Medical Sciences Journal ›› 2014, Vol. 29 ›› Issue (4): 231-235.doi: 10.1016/S1001-9294(14)60076-6

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Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis

Xuan Zhou, Xue-feng Yang*   

  1. Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China
  • Received:2014-09-19 Online:2014-11-28 Published:2014-11-28
  • About author:*Corresponding author Tel: 86-734-8358010, Fax: 86-734-8358399, E-mail: yxf9988@126.com
  • Supported by:
    Supported by National Natural Science Foundation of China (81373465)

Abstract: Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming growth factor-beta (TGF-β), which is the fibrogenic master cytokine, can induce the activation of HSCs to produce a large amount of ECM, and is capable of inducing apoptosis of liver cells. RNA interference (RNAi) is a novel gene disruption technology. Studies have shown that small interfering RNA (siRNA) targeting TGF-β1 may inhibit the activation and proliferation of HSCs, suppress ECM synthesis and block liver fibrosis. TGF-β1 siRNA-mediated gene silencing therapy provides a new avenue for liver fibrosis. This review summarizes recent progresses in research on HSCs, TGF-β1 and TGF-β1 siRNA in liver fibrosis.

Key words: liver fibrosis, hepatic stellate cells, transforming growth factor-β, small interfering RNA

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