Chinese Medical Sciences Journal ›› 2015, Vol. 30 ›› Issue (2): 84-89.doi: 10.1016/S1001-9294(15)30017-1

• Original Articles • Previous Articles     Next Articles

Effect of Neoadjuvant Chemotherapy Treatment on Prognosis of Patients with Advanced Gastric Cancer: a Retrospective Study

Shu-bo Tian, Jian-chun Yu*, Wei-ming Kang, Zhi-qiang Ma, Xin Ye, Chao Yan, Ya-kai Huang   

  1. Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2015-02-24 Online:2015-07-02 Published:2015-07-02
  • Contact: *Corresponding author Tel: 86-10-69152215, E-mail: yu-jch@163.com
  • Supported by:

    △Supported by Beijing Municipal Natural Science Foundation of China (7132209) and Special Found of the Capital Health Research and Deve- lopment (2014-3-4014)

Abstract:

Objective To evaluate the prognostic effects of neoadjuvant chemotherapy (NAC) in patients with local advanced gastric cancer.Methods We retrospectively analyzed prognosis in 191 patients with advanced gastric cancer, of whom 71 were treated with NAC and 120 received surgery only between February 2007 and July 2013. Postoperative complication rate was recorded. Survival by clinicopathological features, pathological T and N stages, and histopathological tumor regression was retrospectively compared between the two groups.Results According to Response Evaluation Criteria in Solid Tumors, none of the 71 patients in the NAC followed by surgery group showed complete response, 36 showed partial response, 25 had stable disease, and 10 had progressive disease. The chemotherapy response rate was 50.7%; the disease control rate was 85.9%. Grade 3/4 adverse events were seen in less than 20% patients, with acceptable toxicities. No difference was found in the overall postoperative complication rates between the two groups (7 versus 22 cases, P=0.18). Median survival time was significantly different, at 54 months in the NAC combined with surgery group and 25 months in the surgery-only group (P=0.025).Conclusion In patients with operable gastric adenocarcinomas, NAC can significantly improve overall survival without increasing surgical complications.

Key words: gastric cancer, neoadjuvant chemotherapy, prognosis, survival analysis

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