大麻素CB1受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

doi:10.24920/004087

Abstract

Objective We aimed to investigate whether antagonism of the cannabinoid CB₁ receptor (CB₁R) could affect novel object recognition (NOR) memory in chronically rapid eye movement sleep-deprived (RSD) rats.

Methods The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique. The CB₁R antagonist rimonabant (1 or 3 mg/kg, i.p.) was administered either at one hour prior to the sample phase for acquisition, or immediately after the sample phase for consolidation, or at one hour before the test phase for retrieval of NOR memory. For the reconsolidation task, rimonabant was administered immediately after the second sample phase.

Results The RSD episode impaired acquisition, consolidation, and retrieval, but it did not affect the reconsolidation of NOR memory. Rimonabant administration did not affect acquisition, consolidation, and reconsolidation; however, it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.

Conclusions These findings, along with our previous report, would seem to suggest that RSD may affect different phases of recognition memory based on its duration. Importantly, it seems that the CB₁R may, at least in part, be involved in the adverse effects of chronic RSD on the retrieval, but not in the acquisition, consolidation, and reconsolidation, of NOR memory.

Key words: REM sleep deprivation, novel object recognition memory, cannabinoid CB₁ receptor, rimonabant

Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, Mehdi Khodamoradi. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J].Chinese Medical Sciences Journal, 2023, 38(1): 29-37.

Figures/Tables 6

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Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	27.54 ± 2.64	21.52 ± 3.03	10.64 ± 1.33	32.40 ± 3.38***
RSD	24.80 ± 2.50	19.41 ± 2.16	18.19 ± 3.07	20.63 ± 2.99
RSD-Veh	23.45 ± 2.52	17.96 ± 2.21	17.08 ± 3.53	18.85 ± 2.62
RSD-R 1 mg/kg	24.27 ± 2.49	19.18 ± 2.14	18.69 ± 2.99	19.67 ± 3.06
RSD-R 3 mg/kg	23.18 ± 2.56	20.23 ± 2.21	17.60 ± 1.88	22.85 ± 3.83

Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	26.98 ± 2.36	21.34 ± 3.05	10.27 ± 1.85	32.40 ± 3.07***
RSD	23.26 ± 2.38	20.32 ± 2.02	16.78 ± 1.74	23.86 ± 3.25
RSD-Veh	25.21 ± 2.72	18.49 ± 2.26	15.96 ± 2.50	21.02 ± 3.58
RSD-R 1 mg/kg	24.01 ± 2.22	20.61 ± 2.02	16.94 ± 1.80	24.27 ± 3.23
RSD-R 3 mg/kg	24.61 ± 2.43	19.40 ± 1.87	16.25 ± 1.69	22.54 ± 3.04*

Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	28.37 ± 2.58	22.77 ± 3.58	10.97 ± 1.77	34.56 ± 3.67**
RSD	24.12 ± 2.91	18.58 ± 2.01	15.98 ± 1.72	21.17 ± 3.42
RSD-Veh	24.41 ± 2.52	19.33 ± 1.92	17.10 ± 2.00	21.57 ± 3.12
RSD-R 1 mg/kg	23.05 ± 2.70	20.28 ± 2.17	15.96 ± 1.90	24.61 ± 3.39*
RSD-R 3 mg/kg	22.91 ± 2.32	20.57 ± 2.20	16.07 ± 2.07	25.07 ± 3.32**

Groups	Time spent exploring objects during the 1^st sample phase (s)	Time spent exploring objects during the 2^nd sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	26.61 ± 2.72	22.94 ± 2.41	24.34 ± 3.24	12.23 ± 1.93	36.45 ± 2.99
RSD	24.99 ± 2.23	23.38 ± 2.31	22.36 ± 2.78	15.61 ± 2.60	29.11 ± 3.75
RSD-Veh	24.86 ± 2.69	23.22 ± 2.18	22.18 ± 2.47	16.91 ± 2.68	27.44 ± 3.33
RSD-R 1 mg/kg	25.05 ± 2.37	23.67 ± 2.38	23.51 ± 2.77	17.88 ± 2.38	29.14 ± 4.33
RSD-R 3 mg/kg	25.44 ± 2.37	22.65 ± 1.90	23.82 ± 2.79	17.88 ± 3.18	29.76 ± 3.74

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