Chinese Medical Sciences Journal ›› 2010, Vol. 25 ›› Issue (1): 27-31.doi: 10.1016/S1001-9294(10)60016-8

• Original Article • Previous Articles     Next Articles

Prevalence of Anti-endothelial Cell Antibodies in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases

Meng-tao Li1; Jun Ai1; Zhuang Tian2; Quan Fang2; Wen-jie Zheng1; Xue-jun Zeng1; and Xiao-feng Zeng1   

  1. 1Department of Rheumatology; 2Department of Cardiology; Peking Union Medical College Hospital; Chinese Academy of Medical Sciences & Peking Union Medical College; Beijing 100730; China
  • Online:2010-03-10 Published:2010-03-10

Abstract: Objective To investigate the prevalence of anti-endothelial cell antibodies (AECAs) in the sera of connective tissue diseases (CTD) patients with pulmonary arterial hypertension (PAH) and its correlation with clinical manifestations. Methods AECAs in sera of 39 CTD patients with PAH,22 CTD patients without PAH,and 10 healthy donors as controls were detected with Western blotting. The prevalence of different AECAs in different groups was compared and its correlation with clinical manifestations was also investigated. Results The prevalence of AECAs was 82.1% in CTD patients with PAH,72.7% in CTD patients without PAH,and 20.0% in healthy donors. Anti-22 kD AECA was only detected in CTD patients with PAH (15.4%). Anti-75 kD AECA was more frequently detected in CTD patients with PAH than in those without PAH (51.3% vs. 22.7%,P<0.05). In CTD patients with PAH,anti-75 kD AECA was more frequently detected in those with Raynaud’s phenomenon or with positive anti-RNP antibody. Conclusion AEC As could be frequently detected in CTD patients with or without PAH,while anti-22 kD and anti-75 kD AECA might be specific in CTD patients with PAH.

Key words: connective tissue diseases, pulmonary arterial hypertension, anti-endothelial cell antibodies

Funding: Supported by Chinese National Key Technology R&D Program (2006BAI01A07, 2008BAI59B02);; Clinical Grant of Chinese Medicine Association (08010270105)

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