Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (4): 377-382.doi: 10.24920/003799

• 病例报告 • 上一篇    下一篇



  1. 1南方医科大学南方医院乳腺科,广州 510515,中国
    2陕西省人民医院血液病研究室,西安 710068,中国
  • 接受日期:2020-07-17 出版日期:2020-12-31 发布日期:2021-01-08
  • 通讯作者: 董建宇

Trastuzumab-Induced Severe Thrombocytopenia:A Case Report and Literature Review

Xiaoqi Zeng1,Shanshan Jiang2,Yuanyang Peng1,Minfeng Liu1,Changsheng Ye1,Jianyu Dong1,*()   

  1. 1Breast Center, Department of General Surgery, Nanfang Hospital,Southern Medical University, Guangzhou 510515, China
    2Institute of Hematological Research, Shaanxi Provincial People’s Hospital, Xi’an 710000, China
  • Accepted:2020-07-17 Published:2020-12-31 Online:2021-01-08
  • Contact: Jianyu Dong



关键词: 乳腺癌, 曲妥珠单抗, 血小板, 血小板减少症


We present a 29-year-old woman with pT2N0M0 breast cancer, histological diagnosis of invasive ductal carcinoma, ER and PR low positive, and HER-2 (3+). The patient developed trastuzumab-induced thrombocytopenia in 6 hours after an intravenous infusion of trastuzumab at the second cycle of trastuzumab treatment with the symptom of abnormal uterine bleeding. Laboratory exam revealed a sharp drop of platelet count down to 3×109/L. With the treatment of single-donor platelet transfusions, glucocorticoids, oxytocin and thrombopoietic drugs, the platelet count recovered completely in 11 days. This case was confirmed to be severe thrombocytopenia induced by trastuzumab, and retreatment with trastuzumab was not attempted. With increasing clinical utilization of trastuzumab, clinicians are likely to encounter more life-threatening trastuzumab induced severe thrombocytopenia. By this case report and literature review, we hope to increase the awareness, attach the attentions to this condition, and help with the effective treatment.

Key words: breast cancer, trastuzumab, platelet, thrombocytopenia

基金资助: 南方医科大学南方医院院长基金(2016L007)

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