Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (3): 282-286.doi: 10.24920/004084

• 医史印迹 • 上一篇    

新中国抗生素研发与工业化生产的不二功勋——张为申

于滨,黄付敏,汤国星,刘静*()   

  1. 中国医学科学院 北京协和医学院,北京100730,中国
  • 收稿日期:2022-03-17 接受日期:2022-07-12 出版日期:2022-09-30 发布日期:2022-09-22
  • 通讯作者: 刘静 E-mail:ljmarry@sina.com

Zhang Weishen: A Pioneer in the Development and Industrial Production of Penicillin in New China

Bin Yu,Fumin Huang,Guoxing Tang,Jing Liu*()   

  1. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
  • Received:2022-03-17 Accepted:2022-07-12 Published:2022-09-30 Online:2022-09-22
  • Contact: Jing Liu E-mail:ljmarry@sina.com

摘要:

青霉素的研发在旧中国艰难起步,并取得了一定的成果。1951年,张为申作为唯一一位在美国青霉素研发中心接受培训和工作多年的华裔科学家,克服重重困难回到中国。1953年,在他和同事们的努力下,中国实现了青霉素的工业化生产,缓解了广大群众的燃眉之急。抗生素也成为新中国成立后第一个取得重大科技成果的学科。20世纪50年代中期,乳糖替代品国产化的技术突破,标志着产青霉素培养基原料的国产化,为中国特色青霉素的产业化生产铺平了道路。抗生素成为中国数亿患者使用率最高、价格最实惠的药物之一,中国从此结束了“东亚病夫”的屈辱历史。

关键词: 青霉素, 研发, 工业化生产, 张为申

Abstract:

The research and development of penicillin started with difficulty before 1949 and achieved certain results. In 1951, after the founding of the People’s Republic of China, Zhang Weishen, as the only Chinese scientist who had been trained and worked in a penicillin research and development center in the United States for many years, overcame many difficulties and returned to China. In 1953, with the efforts of Zhang Weishen and his colleagues, China realized the industrialized production of penicillin, alleviating the urgent needs of the masses. Antibiotics has also become the first discipline to achieve major scientific and technological achievements after the founding of the New China. In the mid-1950s, the technical breakthrough in the localization of lactose substitutes marked the localization of the raw materials of the penicillin-producing culture medium, which paved the way for the industrialized production of penicillin with Chinese characteristics. Antibiotics have become one of the most widely used and affordable drugs for hundreds of millions of patients in China, and China has since ended the humiliating history of the “Sick Man of East Asia”.

Key words: penicillin, antibiotics, research and development, industrial production, Zhang Weishen

基金资助: 北京市社会科学基金重点项目“北京医学博物馆的历史文化与传播创新研究”(21LSA001)

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