无创肠鸣音分析诊断肠易激综合征的准确性：系统综述和荟萃分析

doi:10.24920/004307

Chinese Medical Sciences Journaldoi: 10.24920/004307

无创肠鸣音分析诊断肠易激综合征的准确性：系统综述和荟萃分析

闫夏晓^1,2#, 张越伦^3#, 张钰佩^2#, 杨莹韵¹, 吴东^1,*

¹中国医学科学院北京协和医学院北京协和医院消化内科,疑难重症及罕见病国家重点实验室,北京 100730;
²中国医学科学院北京协和医学院临床医学八年制,北京 100730
³中国医学科学院北京协和医学院北京协和医院医学科学研究中心,北京 100730

收稿日期:2023-10-16 接受日期:2024-02-07 发布日期:2024-04-10

Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

Xia-Xiao Yan^1,2#, Yue-Lun Zhang^3#, Yu-Pei Zhang^2#, Ying-Yun Yang¹, Dong Wu^1*

¹Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
²Eight-Year Medical Doctor Program, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;
³Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Received:2023-10-16 Accepted:2024-02-07 Online:2024-04-10
Contact: ^*E-mail: wudong@pumch.cn
About author:^#Contributed equally to the article.

摘要/Abstract

摘要： 目的采用系统回顾和荟萃分析评估肠鸣音分析对肠易激综合征（irritable bowel syndrome,IBS）的诊断准确性。
方法检索MEDLINE,EMBASE,Cochrane Library,Web of Science和IEEE Xplore数据库中有关肠鸣音分析对IBS诊断准确性的横断面和病例对照研究。检索截止时间为2023年9月。计算灵敏度、特异度、阳性似然比、阴性似然比和诊断比值比及95%置信区间（confidence interval, CI）,并绘制受试者工作特征曲线,计算曲线下面积。
结果共纳入4项研究。肠鸣音分析诊断IBS的灵敏度、特异度、阳性似然比、阴性似然比和诊断比值比分别为0.94（95% CI,0.87~0.97）,0.89（95% CI,0.81~0.94）,8.43（95% CI,4.81~14.78）,0.07（95% CI,0.03~0.15）和118.86（95% CI,44.18~319.75）,曲线下面积为 0.97（95% CI,0.95~0.98）。
结论肠鸣音分析是一种诊断IBS的有效工具。然而,由于高质量研究数据有限,结果的真实性和适用性存疑,需要开展更多临床诊断试验,并优化可穿戴设备进行肠鸣音监测和分析。

关键词: 肠易激综合征, 肠鸣音分析, 诊断准确性, 系统综述, 荟萃分析

Abstract: Objective To assess the diagnostic accuracy of bowel sound analysis for irritable bowel syndrome (IBS) with a systematic review and meta-analysis.
Methods We searched MEDLINE, EMBASE, the Cochrane Library, Web of Science, and IEEE Xplore databases until September 2023. Cross-sectional and case-control studies on diagnostic accuracy of bowel sound analysis for IBS were identified. We estimated the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio with a 95% confidence interval (CI), and plotted a summary receiver operating characteristic curve and evaluated the area under the curve.
Results Four studies were included. The pooled diagnostic sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.94 (95% CI, 0.87－0.97), 0.89 (95% CI, 0.81－0.94), 8.43 (95% CI, 4.81－14.78), 0.07 (95% CI, 0.03－0.15), and 118.86 (95% CI, 44.18－319.75), respectively, with an area under the curve of 0.97 (95% CI, 0.95－0.98).
Conclusions Computerized bowel sound analysis is a promising tool for IBS. However, limited high-quality data make the results' validity and applicability questionable. There is a need for more diagnostic test accuracy studies and better wearable devices for monitoring and analysis.

Key words: irritable bowel syndrome, bowel sound analysis, diagnostic accuracy, systematic review, meta-analysis

基金资助: 国家自然科学基金（32170788）,国家临床重点专科建设项目（ZK108000）,中央高水平医院临研专项（2022-PUMCH-B-023）,北京市自然科学基金（7232123）; Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis 同意标题修改,作者及基金信息有更新,谢谢

Xia-Xiao Yan, Yue-Lun Zhang, Yu-Pei Zhang, Ying-Yun Yang, Dong Wu. Diagnostic Accuracy of Computerized Bowel Sound Analysis with Non-Invasive Devices for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis[J/OL].Chinese Medical Sciences Journal, .DOI:10.24920/004307.[Epub ahead of print].

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