Chinese Medical Sciences Journal ›› 2018, Vol. 33 ›› Issue (2): 120-126.doi: 10.24920/21805

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  1. 中国医学科学院 北京协和医学院,北京协和医院 血管外科, 北京 100730 中国
  • 收稿日期:2017-08-08 出版日期:2018-06-30 发布日期:2018-06-13
  • 通讯作者: 陈跃鑫

A Literature Review of Antithrombotic Therapy for Patients of Venous Thromboembolic Events with Comorbidity of Coronary Heart Disease

Zhou Mengxin,Sun Rui,Chen Yuexin()   

  1. Department of Vascular Surgery, Peking Union Medical College Hospital,Chinese Medical Sciences Academy & Peking Union Medical College,Beijing 100730, China
  • Received:2017-08-08 Published:2018-06-30 Online:2018-06-13
  • Contact: Chen Yuexin



关键词: 静脉血栓栓塞症, 冠心病, 抗栓治疗, 联合治疗


Patients with venous thromboembolism (VTE) and concurrent coronary heart disease (CHD) are not rare in clinic. The main challenge in the treatment for these patients is that the antithrombotic therapies for VTE and CHD are different from each other, but the combination of the two therapeutic strategies would increase the risk of bleeding. There is a need to optimize the antithrombotic therapeutic scheme on the basis of individual conditional, in order to balance the therapeutic effects and the bleeding risk. This article discussed the appropriate antithrombotic therapy when balancing the effectiveness and the risk in different circumstance of concurrence of VTE and CHD, such as combining anticoagulation therapy, dual antiplatelet therapy (DAPT), triple antithrombotic therapy (TAT), thrombolytic therapy and extending therapy, in order to provide safe, standard and effective therapeutic schemes for the clinical management of these patients. In the meantime, this article also provides perspectives regarding the application of novel non-vitamin K anticoagulants (NOACs) and the assessment tools of bleeding risk.

Key words: venous thromboembolism, coronary heart disease, antithrombotic therapy, combination therapy

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