Chinese Medical Sciences Journal ›› 2011, Vol. 26 ›› Issue (2): 109-112.doi: 10.1016/S1001-9294(11)60029-1

• Original Article • Previous Articles     Next Articles

Changes of Nerve Growth Factor in Amniotic Fluid and Correlation with Ventriculomegaly

Xiao-yan Xia1, Xing-hua Huang1, Yi-xin Xia2*, and Wei-hua Zhang1   

  1. 1Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital , Capital Medical University , Beijing 100026, China
    2Department of Obstetrics and Gynecology, General Hospital of Armed Police Forces, Beijing 100039, China
  • Received:2011-06-24 Revised:2011-06-24 Online:2011-06-24 Published:2011-06-24

Abstract: Objective To detect the change of nerve growth factor (NGF) level in human amniotic fluid during gestation, and to explore the relationship between this change and fetal ventriculomegaly (VM).
Methods The studied subjects (collected from 2004 to 2007) were divided into four groups, including the second-trimester pregnancy group (n=113), third-trimester pregnancy group (n=110), fetal cerebral VM group (n=12), and healthy control group (n=12) which matched with the VM group in gestational weeks. The amniotic fluid specimens were obtained during amniocentesis or cesarean section. The NGF levels in amniotic fluid were detected with enzyme-linked immunosorbent assay.
Results A significantly negative correlation was found between gestational age and the NGF level in amniotic fluid (r=−0.6149, P<0.0001). The NGF level in patients with fetal VM was significantly lower than that in healthy controls (33.95±29.24 pg/mL vs. 64.73±16.21 pg/mL, P=0.024).
Conclusion NGF levels in amniotic fluid may be a sensitive marker for fetal VM.

Key words: nerve growth factor, amniotic fluid, fetal ventriculomegaly

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