Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (4): 371-376.doi: 10.24920/003603

• Case Report • Previous Articles     Next Articles

Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review

Jie Zhao1, Yimeng Yang2, Shuhong Ming2, *()   

  1. 1Department of Medical Oncology, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
    2Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China
  • Received:2019-05-08 Accepted:2019-09-06 Published:2020-12-31 Online:2020-09-29
  • Contact: Shuhong Ming

Hemophagocytic lymphohistiocytosis (HLH) is a rare but devastating disease characterized by dysregulated immune response and hyperinflammation. To our knowledge, pregnancy-induced HLH has been rarely reported in the literature. A 30-year-old pregnant woman presented persistent fever for 21 days since 17 weeks of pregnancy. The possible etiologies such as infection, autoimmune disorder, and malignancy had been ruled out based on a series of exhaustive examinations. The disease progressed despite the use of broad-spectrum antibiotics and dexamethasone. The patient was diagnosed as pregnancy-induced HLH, and finally recovered completely after termination of pregnancy by caesarean and the continuous use of glucocorticoid which played a crucial part in controlling hyperinflammation. Pregnancy-induced HLH could be fatal if effective treatment was not initiated timely. Further studies are needed to improve early diagnosis and etiology identification of HLH.

Key words: hemophagocytosis, hyperinflammation, pregnancy

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