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Biomarkers with Potential Predictive Value for Cardiotoxicity in Anticancer Treatments

Wei Yang, Mei Zhang*   

  1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China

Abstract: The rapid development of anticancer treatments in recent years has greatly improved the prognosis of cancer patients. However, with the extension of the survival time of cancer patients, various short-term and long-term side effects brought about by anticancer treatments, especially the problem of cardiotoxicity, have become increasingly prominent. Nonetheless, at this stage, there is no diagnostic method with extremely high sensitivity and specificity to detect and accurately predict whether patients with malignant tumors will experience cardiovascular complications. Inflammation, fibrosis and oxidative stress are considered to be important mechanisms for anticancer treatments to cause cardiotoxicity. The related cardiovascular biomarkers may detect cardiovascular dysfunction earlier than clinical symptoms and left ventricular ejection fraction monitored by echocardiography, which is of great value for timely adjustment of treatment and prognosis evaluation. Cardiac troponin T/I and brain natriuretic peptide/N-terminal prohormone of brain natriuretic peptide have been recommended to be routinely used in clinical practice to monitor cardiotoxicity, and some new biomarkers such as soluble suppression of tumorigenecity-2, myeloperoxidase, growth differentiation factor-15, galectin-3, endothelin-1, have potential research value. Before being applied to clinical practice, larger-scale experimental studies are needed to provide sufficient evidence, and how to detect them quickly and at low cost is also a problem to be considered. 

Key words: biomarkers;, cardiotoxicity;, anticancer treatments;, review

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