Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (4): 359-362.doi: 10.24920/003999

• Case Report • Previous Articles    

Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report

Xin He1, Jianping Ning2, Hui Xu2, Gong Xiao2, Huixiang Yang1, Weiyuan Wang3, Xiaoying Wu3, Hongling Yin3, *(), Xiaozhao Li2, *()   

  1. 1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China
    2Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China
    3Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China
  • Received:2021-09-13 Accepted:2022-04-01 Published:2022-12-31 Online:2022-06-28
  • Contact: Hongling Yin,Xiaozhao Li;

Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.

Key words: anti-neutrophil cytoplasmic antibody-associated vasculitis, amyloidosis

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