ANCA相关血管炎继发肾淀粉样变性：1例病例报告

doi:10.24920/003999

Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (4): 359-362.doi: 10.24920/003999

Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report

Xin He¹, Jianping Ning², Hui Xu², Gong Xiao², Huixiang Yang¹, Weiyuan Wang³, Xiaoying Wu³, Hongling Yin^3,^*(), Xiaozhao Li^2,^*()

¹Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China
²Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China
³Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China

Received:2021-09-13 Accepted:2022-04-01 Published:2022-12-31 Online:2022-06-28
Contact: Hongling Yin,Xiaozhao Li E-mail:Yhl99@yahoo.com.cn;lixiaozhao@csu.edu.cn

Abstract

Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.

Key words: anti-neutrophil cytoplasmic antibody-associated vasculitis, amyloidosis

Xin He, Jianping Ning, Hui Xu, Gong Xiao, Huixiang Yang, Weiyuan Wang, Xiaoying Wu, Hongling Yin, Xiaozhao Li. Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report[J].Chinese Medical Sciences Journal, 2022, 37(4): 359-362.

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References 7

[1]	Cornec D, Cornec-Le Gall E, Fervenza FC, et al. ANCA-associated vasculitis—clinical utility of using ANCA specificity to classify patients. Nat Rev Rheumatol 2016; 12(10):570-9. doi: 10.1038/nrrheum.2016.123. doi: 10.1038/nrrheum.2016.123 pmid: 27464484
[2]	Hilhorst M, van Paassen P, Tervaert JW, et al. Proteinase 3-ANCA vasculitis versus myeloperoxidase-ANCA vasculitis. J Am Soc Nephrol 2015; 26(10):2314-27. doi: 10.1681/ASN.2014090903. doi: 10.1681/ASN.2014090903 pmid: 25956510
[3]	Westermark GT, Fandrich M, Westermark P. AA amyloidosis: pathogenesis and targeted therapy. Annu Rev Pathol 2015; 10:321-44. doi: 10.1146/annurev-pathol-020712-163913. doi: 10.1146/annurev-pathol-020712-163913 pmid: 25387054
[4]	Papa R, Lachmann HJ. Secondary, AA, amyloidosis. Rheum Dis Clin North Am 2018; 44(4):585-603. doi: 10.1016/j.rdc.2018.06.004. doi: 10.1016/j.rdc.2018.06.004
[5]	Brunger A, Nienhuis H, Bijzet J, et al. Causes of AA amyloidosis: a systematic review. Amyloid 2020; 27(1):1-12. doi: 10.1080/13506129.2019.1693359. doi: 10.1080/13506129.2019.1693359 pmid: 31766892
[6]	Maamar M, Tazi-Mezalek Z, Harmouche H, et al. Churg-Strauss syndrome associated with AA amyloidosis: a case report. Pan Afr Med J 2012; 12:30.
[7]	Ubara Y, Tagami T, Suwabe T, et al. Systemic AA-amyloidosis related to MPO-ANCA microscopic polyangiitis: a case report. Amyloid 2006; 13(3):178-83. doi: 10.1080/13506120600876815. doi: 10.1080/13506120600876815 pmid: 17062385

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