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Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (2): 138-146.doi: 10.24920/004159
• Review • Previous Articles Next Articles
Fatemeh Mashhadiabbas1, Sanaz GholamiToghchi1, Roohollah Safarpour2()
Received:
2022-08-19
Accepted:
2023-03-14
Published:
2023-06-30
Online:
2023-04-14
Contact:
*98-917-7737642, 98-663-3207826, E-mail: Fatemeh Mashhadiabbas, Sanaz GholamiToghchi, Roohollah Safarpour. Central Granular Cell Odontogenic Tumor: A Literature Review of Cases Reported in the Last 71 Years with a New Case Report[J].Chinese Medical Sciences Journal, 2023, 38(2): 138-146.
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Figure 3.
Histopathological results of a 39-year-old white female with CGCOT. HE staining (A) Sheets and lobules of eosinophilic granular cells are intermixed with cords and strands of odontogenic epithelium. (B) Large granular cells with eccentric vesicular nuclei and vacuolated odontogenic epithelium (arrow)."
Figure 4.
Immunohistochemical results of a 39-year-old white female with CGCOT. EnVision staining (A) Granular cells are positive for CD68, and odontogenic epithelium is negative for CD68. (B) Granular cells are positive for vimentin, whereas odontogenic epithelium is negative for vimentin. (C) Granular cells are negative for S-100."
Table 1.
Demographic and clinical findings of 51 reported cases with CGCOT in the literatures"
References | Year of publication | Age (yrs) | Gender | Location | Radiographic features | Treatment | Follow-up |
---|---|---|---|---|---|---|---|
Werthemann[ | 1950 | 39 | Male | Left mandibular premolar/molar | NS | NS | NS |
Couch et al.[ | 1962 | 55 | Femle | Left mandibular second molar | Radiolucent lesion with loculated borders | Conservative removal of the lesion with tooth extraction | NR 8 months |
Couch et al.[ | 1962 | 59 | Female | Left mandibular canine | Loculated radiolucency with focal densities | Removal of tumor | NR 27 months |
Waldron et al.[ | 1963 | 60 | Female | Left mandibular canine | 2.0 cm radiolucent lesion | Removal of tumor | NR 29 months |
Waldron et al.[ | 1963 | 53 | Female | Left mandibular molar | 2.0-3.0 cm cystic radiolucency, displacment of teeth | Removal of the mass with tooth extraction | NR 3 months |
Gorlin et al.[ | 1970 | 50 | Female | Mandibular molar region | NS | Curettage | NS |
Dalforno et al.[ | 1970 | 57 | NS | Left mandibular molar | NS | Curettage | NR 6 months |
White et al.[ | 1978 | 50 | Female | Mandibular canine area | Radiolucency | Curettage | NR 6 months |
White et al.[ | 1978 | 50 | Female | Mandibular posterior area | Radiolucency | Curettage | NR 7 years |
White et al.[ | 1978 | 55 | Female | Maxillary premolar | Radiolucency | Surgical excision | NR 3 years |
White et al.[ | 1978 | 65 | Female | Mandibular premolar/molar | Radiolucency | Surgical excision | NR 2 years |
Regezi et al.[ | 1978 | 29 | Female | Maxilla | NS | NS | NS |
Regezi et al.[ | 1978 | 16 | Male | Mandible | NS | NS | NS |
Vincent et al.[ | 1987 | 51 | Female | Right mandibular premolar/molar | 4-2 cm radiolucency with sclerotic border | Conservative removal of the mass | NS |
Vincent et al.[ | 1987 | 27 | Male | Right mandibular second premolar/first molar | 1.5 cm unicystic radiolucency with sclerotic borders | Surgical excision | NR 24 months |
Shiro et al.[ | 1989 | 45 | Female | Left mandibular premolars | 0.7-0.4 cm unicystic radiolucency | Surgical excision | NR 4 years |
Mirchandani et al.[ | 1989 | 33 | Female | Mandible | Radiolucency | NS | NS |
Ruhl et al.[ | 1989 | 22 | Male | Left maxillary first and second molars | 4.5 cm with slight displacement of teeth | Complete resection | NS |
Chen[ | 1991 | 50 | Female | Right mandibular canine | 1.0-0.8 cm radiolucency | NS | NS |
Chen[ | 1991 | 45 | Female | Left mandibular premolar/molar | 5.0-3.0 cm radiolucency | NS | NS |
Chen[ | 1991 | 64 | Female | Left mandibular canine/premolar | 3.0-2.0 cm radiolucency | NS | NS |
Chen[ | 1991 | 77 | Female | Left mandibular premolars | 0.5-0.5 cm radiolucency | NS | NS |
Yih et al.[ | 1995 | 66 | Female | Left mandibular second premolar | 0.5-0.5 cm unilocular radiolucency | Curettage | NR 6 months |
Gesek et al.[ | 1995 | 62 | Female | Left mandibular second premolar | Multilocular, well-circumscribed radiolucency | Curettage | NR 12 months |
Machado de Sousa et al.[ | 1998 | 19 | Female | Right maxillary premolar/molar | Well-delineated multilocular radiolucency | Surgical excision | NR 24 months |
Machado de Sousa et al.[ | 1998 | 25 | Male | Right maxillary premolar/molar | 8.0 cm radiopaque lesion | Surgical excision | NR 120 months |
Ardekian et al.[ | 1998 | 63 | Male | Right maxillary premolar/molar | Well-defined radiolucency with sclerotic border | Curettage Teeth extraction | NR 48 months |
Matsumoto et al.[ | 2000 | 24 | Male | Left mandibular premolars | Well-demarcated radiolucent lesion | Enucleation with teeth extraction | NR 1.5 years |
Brannon et al.[ | 2002 | 36 | Female | Mandibular canine/ premolar | NS | NS | NS |
Brannon et al.[ | 2002 | 50 | Female | Jaw | NS | NS | NS |
Brannon et al.[ | 2002 | 32 | Female | Mandibular canine/ premolar | Multilocular radiolucency with sclerotic border | Teeth extraction with surgical excision | NR 180 months |
Brannon et al.[ | 2002 | 19 | Female | Left maxillary first premolar/first molar | Unicystic radiolucency enveloping roots of second premolar | Curettage | Recurrence 156 months |
Brannon et al.[ | 2002 | 48 | Male | Right side of maxilla | NS | NS | NS |
Calvo et al.[ | 2002 | 61 | Male | Anterior region of maxilla | Radiolucency with resorption of anterior teeth | NS | NS |
Meer et al.[ | 2004 | 65 | Female | Left mandibular first premolar/second molar | Irregular radiolucency from first premolar to second molar | Surgical excision | NR 12 months |
Reichart et al.[ | 2006 | 46 | Female | Right mandibular premolar/molar | Multilocular radiolucent lesion | Surgical excision with reconstruction | NR 2 yrs. |
Gomes et al.[ | 2006 | 20 | Female | Left mandibular premolars/molars | An intra-osseous mixed lesion, 5 cm | Enucleation | NR 7 months |
Kim et al.[ | 2006 | 33 | Male | Right maxillary premolar/first molar | Well-defined unilocular radiolucency | Enucleation with tooth extraction | NR 23 months |
Mesquita et al.[ | 2009 | 20 | Female | Left mandibular second premolar/second molar | Well-defined radiolucency with foci of calcifications | Complete resection of tumor | NR 4 years |
Lotay et al.[ | 2010 | 28 | Female | Right maxillary premolar | 1.5-2.5 cm well-defined mixed lesion | Enucleation and curettage | NS |
Silva et al.[ | 2012 | 41 | Female | Left side of maxilla | Well-defined mixed lesion | Surgical excision | NR 2 years |
Sarode et al.[ | 2013 | 25 | Female | Right side of mandible crossing the midline | Well-demarcated multilocular radiolucent lesion | Enucleation and curettage | NR 2 years |
Cheng et al.[ | 2013 | 52 | Female | Right mandibular premolars | Well-defined mixed lesion | Enucleation | NR 3 months |
Chiang et al.[ | 2014 | 69 | Male | Ramus of left mandible | Well-demarcated radiolucent lesion | Surgical excision | NR 2 months |
Anbiaee et al.[ | 2014 | 16 | Female | Left mandibular angle | Multilocular mixed lesion, 3 cm × 5 cm | Surgical resection with mandibular reconstruction | NR 2 years |
Lee et al.[ | 2014 | 19 | Male | Left mandibular third molar | Enlarged dental follicle | Enucleation with tooth extraction | NS |
Fletcher et al.[ | 2015 | 19 | Female | Right mandibular second premolar/molars | Unilocular radiolucent lesion | Curettage | NR 24 months |
Vennamaneni et al.[ | 2016 | 38 | Male | Right mandibular premolars/first molar | Well-defined unilocular radiolucent lesion | Enucleation | NR NS |
Madan et al.[ | 2016 | 73 | Male | Anterior area of mandible | Multilocular radiolucent lesion | Segmental resection | NR 9 months |
Atarbashi- Moghadam et al.[ | 2019 | 57 | Female | Left mandibular premolars/first molar | Well defined radiolucent lesion | Enucleation | NR 12 months |
Koth et al.[ | 2021 | 42 | Femlae | Left maxillary anterior region | Unilocular radiolucency | Surgical removal | NR 16 months |
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