Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (2): 159-162.doi: 10.24920/004208

• Case Report • Previous Articles    

Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case

Li-Ping Zhu, Rui Tang, Qing Wang, Hong Li*()   

  1. Allergy Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2023-01-28 Accepted:2023-04-24 Published:2023-06-30 Online:2023-05-18
  • Contact: *Hong Li, E-mail:

Food-dependent, exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening disorder that often occurs with exercise, and patients typically have eaten a specific food within hours before disease onset. This disease is exceedingly rare, with a prevalence of 0.02%. No well-recognized prevention or treatment strategy has been available for FDEIA except avoiding triggers strictly. Here we report an 11-year-old boy with a history of recurrent anaphylaxis of unknown etiology more than 10 times within two years. As the anaphylactic symptoms had not been controlled after traditional treatments, the patient was given subcutaneous injection of dupilumab seven times within 33 weeks. During dupilumab treatments, the patient was exposed to culprit mushrooms plus exercises at least twice a month but without notable anaphylaxis. Thus, Dupilumab may improve the allergic reactions in FDEIA patients.

Key words: food-dependent, exercise-induced anaphylaxis, anaphylaxis treatment, food allergy, mushroom allergy, dupilumab

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