Chinese Medical Sciences Journal ›› 2024, Vol. 39 ›› Issue (2): 79-90.doi: 10.24920/004327

• Guideline and Consensus •     Next Articles

A Chinese Multi-Specialty Delphi Consensus to Optimize RAASi Usage and Hyperkalaemia Management in Patients with Chronic Kidney Disease and Heart Failure

Ming-Hui Zhao1, *(), Wei Chen2(), Hong Cheng3(), Bi-Cheng Liu4(), Zhi-Guo Mao5(), Zhuang Tian6(), Gang Xu7(), Jing-Min Zhou9()   

  1. 1Renal Division, Peking University First Hospital, Beijing 100034, China
    2Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China
    3Department of Nephrology, Capital Medical University, Beijing 100029, China
    4Department of Nephrology, Southeast University Zhongda Hospital, Nanjing 210009, China
    5Department of Nephrology, Shanghai Changzheng Hospital, Shanghai 200003, China
    6Department of Cardiology, Peking Union Medical College Hospital, Beijing 100730, China
    7Renal Division, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    8Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • Received:2023-12-05 Accepted:2024-04-08 Published:2024-06-30 Online:2024-06-07
  • Contact: * mhzhao@bjmu.edu.cn.

Objective Variations are present in common clinical practices regarding best practice in managing hyperkalaemia (HK), there is therefore a need to establish a multi-specialty approach to optimal renin-angiotension-aldosterone system inhibitors (RAASi) usage and HK management in patients with chronic kidney disease (CKD) & heart failure (HF).This study aimed to establish a multi-speciality approach to the optimal use of RAASi and the management of HK in patients with CKD and HF.
Methods A steering expert group of cardiology and nephrology experts across China were convened to discuss challenges to HK management through a nominal group technique. The group then created a list of 41 statements for a consensus questionnaire, which was distributed for a further survey in extended panel group of cardiologists and nephrologists across China. Consensus was assessed using a modified Delphi technique, with agreement defined as "strong" (≥75% and <90%) and "very strong" (≥90%). The steering group, data collection, and analysis were aided by an independent facilitator.
Results A total of 150 responses from 21 provinces across China were recruited in the survey. Respondents were comprised of an even split (n=75, 50%) between cardiologists and nephrologists. All 41 statements achieved the 75% consensus agreement threshold, of which 27 statements attained very strong consensus (≥90% agreement) and 14 attained strong consensus (agreement between 75% and 90%).
Conclusion Based on the agreement levels from respondents, the steering group agreed a set of recommendations intended to improve patient outcomes in the use of RAASi therapy and HK management in China.

Key words: Sardiorenal syndrome, chronic kidney failure, heart failure, hyperkalemia, multidisciplinary communication, RAASi

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