Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (4): 253-259.doi: 10.24920/J1001-9294.2017.037
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Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension
Wu Wen1, Li Yan2, Xu Dunquan3, *(
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- 1 Department of Ultrasound, General Hospital of the Army, Beijing 100007, China
2. Medical Examination Center, General Hospital of the Army, Beijing 100007, China
3 Clinical Laboratory, the Xigaze Branch of Xinqiao Hospital, the Army Medical University, Xigaze, Tibet 857000, China
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Received:2016-10-24Published:2017-12-30Online:2017-12-30 -
Contact:Xu Dunquan E-mail:149011273@qq.com
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The author proposed that “ROS/Kv/HIF axis” participate in the process of hypoxia-induced pulmonary vasoconstriction and vascular remodeling, and play an important initial role in the development of hypoxia-induced pulmonary hypertension. |
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Wu Wen, Li Yan, Xu Dunquan. Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension[J].Chinese Medical Sciences Journal, 2017, 32(4): 253-259.
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Figure 1.
Schematic flowchart of the pathway of ROS/ Kv/HIF axis in hypoxia-induced HPH. Hypoxia causes stabilization of HIF-1α, and then leads to the expression of various genes such as VEGF, PDGF and ET-1, all of which participate in HPV and PVR during HPH. Hypoxia induced ROS production affects the balance of K+ and stabilizes the HIF system. VEGF also promotes ROS through the NADPH pathway. ROS increases HIF-1α by inhibiting its degradation. Moreover, NADPH oxidase-derived ROS can inhibit Kv channel current. The imbalance of K+ participates in vasoconstriction and remodeling of pulmonary vessels under hypoxia condition. On the other hand, ROS and HIF promote each other, and form a positive feedback loop, which further disturbs the constriction/dilation of pulmonary vessels and cell proliferation/apoptosis during the pathophysiological progression of HPH. HIF, hypoxia inducible factor; VEGF, vascular endothelial growth factor; PDGF, platelet-derived growth factor; ET, endothelin; HPV, hypoxic pulmonary vasoconstriction; PVR, pulmonary vascular remodeling; ROS, reactive oxygen species; VHL, von Hippel-Lindau; PHD, prolyl hydroxylase domain; HREs, hypoxia response elements; CBP, c-AMP responsive element binding protein; HPH, hypoxic pulmonary hypertension. "
Figure 1.
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