Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (2): 107-112.doi: 10.24920/J1001-9294.2017.018
• Original Article • Previous Articles Next Articles
Ou Qin1, Li Wenfang2, Li Bei1, *(), Yu Chunfang1
Received:
2014-04-17
Published:
2017-06-30
Online:
2017-06-10
Contact:
Li Bei
E-mail:151449176@qq.com
Ou Qin, Li Wenfang, Li Bei, Yu Chunfang. Prevalence of Carbapenem-Resistant Klebsiella Pneumoniae (CRKP) and the Distribution of Class 1 Integron in Their Strains Isolated from a Hospital in Central China[J].Chinese Medical Sciences Journal, 2017, 32(2): 107-112.
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Table 1
Distribution of isolated CRKP strains in departments of a hospital in Shiyan, central China(n=117)"
Department | ICU | Burn | Geriatrics | Emergency | Oncology | General medicine | General surgery | Brain Surgery |
---|---|---|---|---|---|---|---|---|
Strains(n) | 52 | 13 | 11 | 9 | 7 | 5 | 4 | 5 |
Percentage(%) | 44.4 | 11.1 | 9.4 | 7.7 | 6.0 | 4.3 | 3.4 | 4.3 |
Department | Orthopaedics | Neurology | Gastroenteroloy | Respiratory | Cardiology | Hematology | Rheumatology | Thoracic |
Strains(n) | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 |
Percentage(%) | 1.7 | 0.9 | 0.9 | 0.9 | 0.9 | 0.9 | 1.7 | 1.7 |
Table 2
Distribution of antibiotics resistance in 117 strains of CRKP isolated from a hospital in Shiyan, central China [n, (%)]"
Suscepti- bility | Antibiotics | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Ampicillin /Sulbactam | Amikacin | Aztreonam | Tigecycline | Colistin | Imipenem | Meropenem | ||||||
Sensitive | 0 | 9 (7.7) | 3(2.6) | 69(59.0) | 63(53.8) | 1(0.9) | 2(1.7) | |||||
Medium sensitive | 0 | 3(2.6) | 2(1.7) | 33(28.2) | 12(10.3) | 2(1.7) | 3(2.6) | |||||
Resistant | 117(100) | 105(89.7) | 112(95.7) | 15(12.8) | 42(35.9) | 114(97.4) | 112(95.7) | |||||
Suscepti- bility | Antibiotics | |||||||||||
Tobramycin | Ceftazidme | Gentamicin | Cefotaxime | Cefepime | Piperacillin | |||||||
Sensitive | 7(6.0) | 0 | 8(6.8) | 0 | 1(0.9) | 0 | ||||||
Medium sensitive | 6(5.1) | 3(2.6) | 3(2.6) | 0 | 3(2.6) | 2(1.7) | ||||||
Resistant | 104(88.9) | 114(97.4) | 106(90.6) | 117(100) | 113(96.5) | 115(98.3) |
Table 3
Association between class 1 integron and antimicrobial resistant phenotypes in 117 strains of CRKP [n, (%)]"
Class 1 integron | Strains resistant to antibiotics | |||||||
---|---|---|---|---|---|---|---|---|
Ampicillin/ Sulbactam (n=117) | Amikacin (n=105) | Aztreonam (n=112) | Tigecycline (n=15) | Colistin (n=42) | Imipenem (n=114) | Meropenem (n=112) | ||
Negative (n=26) | 26 | 18 | 24 | 5 | 11 | 25 | 25 | |
(100) | (69.2) | (92.3) | (19.2) | (42.3) | (96.2) | (96.2) | ||
Positive (n=91) | 91 | 87 | 88 | 10 | 31 | 89 | 87 | |
(100) | (95.6) | (96.7) | (10.9) | (34.1) | (97.8) | (95.6) | ||
P-value | 1 | 0.001 | 0.328 | 0.268* | 0.440† | 0.220 | 0.903 | |
Class 1 integron | Strains resistant to antibiotics | |||||||
Piperacillin (n=115) | Cefotaxime (n=117) | Cefepime (n=113) | Tobramycin (n=103) | Ceftazidime (n=114) | Gentamicin (n=106) | |||
Negative (n=26) | 25 | 26 | 25 | 17 | 25 | 18 | ||
(100) | (69.2) | (96.2) | (65.3) | (96.2) | (69.2) | |||
positive (n=91) | 90 | 91 | 88 | 86 | 89 | 88 | ||
(98.9) | (95.6) | (96.7) | (94.5) | (97.8) | (96.7) | |||
P-value | 1 | 1 | 1 | 0.000 | 1 | 0.000 |
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