Chinese Medical Sciences Journal ›› 2014, Vol. 29 ›› Issue (1): 1-6.doi: 10.1016/S1001-9294(14)60016-X

• ORIGINAL ARTICLE •     Next Articles

Association of C(-106)T Polymorphism in Aldose Reductase Gene with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus

Yu Deng1, 2, Xiu-fen Yang2, Hong Gu2, Apiradee Lim3, Munkhtulga Ulziibat4, Torkel Snellingen4, Jun Xu2, Kai Ma2, Ning-pu Liu2, *   

  1. 1Department of Ophthalmology, Fu Xing Hospital, Capital Medical University, Beijing 100038, China; 2Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China; 3Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand; 4Sekwa Eye Hospital, Beijing 100088, China
  • Received:2012-12-03 Online:2014-03-31 Published:2014-03-31
  • Contact: Tel:86-10-58269821, E-mail:nliu001@gmail.com
  • Supported by:
    △Supported by the National Basic Research Program of China (973 Program, 2007CB512201), the Beijing Municipal Health Bureau Grant (2009208), and the Beijing Natural Science Foundation (7131007).

Abstract: Objective To identify the possible association between C(-106)T polymorphism of the aldose reductase (ALR) gene and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM).Methods From November 2009 to September 2010, patients with T2DM were recruited and assigned to DR group or diabetic without retinopathy (DWR) group according to the duration of diabetes and the grading of 7-field fundus color photographs of both eyes. Genotypes of the C(-106)T polymorphism (rs759853) in ALR gene were analyzed using the MassARRAY genotyping system and an association study was performed.Results A total of 268 T2DM patients (129 in the DR group and 139 in the DWR group) were included in this study. No statistically significant differences were observed between the 2 groups in the age of diabetes onset (P=0.10) and gender (P=0.78). The success rate of genotyping for the study subjects was 99.6% (267/268), with one case of failure in the DR group. The frequencies of the T allele in the C(-106)T polymorphism were 16.0% (41/256) in the DR group and 19.4% (54/278) in the DWR group (P=0.36). There was no significant difference in the C(-106)T genotypes between the 2 groups (P=0.40). Compared with the wild-type genotype, odds ratio (OR) for the risk of DR was 0.7 (95% CI, 0.38-1.3) for the heterozygous CT genotype and 0.76 (95% CI, 0.18-3.25) for the homozygous TT genotype. The risk of DR was positively associated with microalbuminuria (OR=4.61; 95% CI, 2.34-9.05) and insulin therapy (OR=3.43; 95% CI, 1.94-6.09).Conclusions Microalbuminuria and insulin therapy are associated with the risk of DR in Chinese patients with T2DM. C(-106)T polymorphism of the ALR gene may not be significantly associated with DR in Chinese patients with T2DM.

Key words: diabetic retinopathy, aldose reductase gene, single nucleotide polymorphism

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