Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (3): 265-274.doi: 10.24920/003994
Wnt5a在炎性疾病中具有双向调节性
陈旭1,刘红玲2,李德红3,王金穗1,赵凤辉1,*(
)
- 1甘肃省人民医院病理科,兰州730000,中国
2甘肃省第三人民医院职业病科,兰州730000,中国
3甘肃省人民医院检验科,兰州730000,中国
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收稿日期:2021-09-09接受日期:2022-03-06出版日期:2022-09-30发布日期:2022-05-11 -
通讯作者:赵凤辉 E-mail:zhaofh0931@163.com
Dual Role of Wnt5a in the Progression of Inflammatory Diseases
Xu Chen1,Hongling Liu2,Dehong Li3,Jinsui Wang1,Fenghui Zhao1,*()
- 1Department of Pathology, Gansu Provincial Hospital, Lazhou 730000, China
2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
3Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou 730000, China
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Received:2021-09-09Accepted:2022-03-06Published:2022-09-30Online:2022-05-11 -
Contact:Fenghui Zhao E-mail:zhaofh0931@163.com
摘要：
Wnt5a是一种分泌性的Wnt蛋白,在细胞通路及炎性疾病中扮演重要作用。WNT5A基因可编码形成Wnt5a长链蛋白和Wnt5a短链蛋白,这两种蛋白的形成取决于WNT5A基因启动子甲基化的部位,具有不同的功能。然而,WNT5A基因启动子甲基化的机制目前仍然不清楚。在炎性疾病中,因为WNT5A基因甲基化的部位不同,Wnt5a具有抑制炎症和促进炎症的双面功能,这或许涉及Wnt5a蛋白不同的亚型。因此,Wnt5a蛋白的不同亚型或许是潜在的炎性疾病诊断标记,WNT5A基因甲基化的具体机制也需要深入研究。
引用本文
Xu Chen, Hongling Liu, Dehong Li, Jinsui Wang, Fenghui Zhao. Dual Role of Wnt5a in the Progression of Inflammatory Diseases[J].Chinese Medical Sciences Journal, 2022, 37(3): 265-274.
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| [1] | 陈旭, 刘红玲, 赵凤辉, 焦宗宪, 王金穗, 党雅梅. Wnt5a在肿瘤进展中的作用具有争议性[J]. Chinese Medical Sciences Journal, 2020, 35(4): 357-365. |
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