Chinese Medical Sciences Journal ›› 2011, Vol. 26 ›› Issue (2): 69-76.doi: 10.1016/S1001-9294(11)60023-0

• Original Article •     Next Articles

Erythropoietin Receptor Positive Circulating Progenitor Cells and Endothelial Progenitor Cells in Patients with Different Stages of Diabetic Retinopathy

Liu-mei Hu1, Xia Lei2, 3, Bo Ma4, Yu Zhang5, Yan Yan6, Ya-lanWu3, Ge-zhi Xu4, Wen Ye5, Ling Wang6, Guo-xu Xu7, Guo-tong Xu2, 3, Wei-ye Li1, 2, 3, 8   

  1. 1 Department of Ophthalmology,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences& Peking Union Medical College, Beijing 100730, China 
    2 Tongji Eye Instituteand Department of Regenerative Medicine, Tongji University School of Medicine,Shanghai 200092, China 
    3 Laboratory of Clinical Visual Sciences, Institute ofHealth Sciences, Shanghai Institutes for Biological Sciences, Chinese Academyof Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai200025, China 
    4 Department of Ophthalmology, Eye and ENT Hospital, FudanUniversity, Shanghai 200031, China 
    5 Department of Ophthalmology,Huashan Hospital Affiliated toFudan University ,Shanghai 200040,China 
    6Department ofOphthalmology,Ruijin HospitalAffiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 
    7Department of Ophthalmology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China 
    8Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA 19107, USA
  • Received:2011-06-24 Revised:2011-06-24 Online:2011-06-24 Published:2011-06-24

Abstract: Objective To investigate the possible involvement of erythr opoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR). Methods EPOR positive circulating progenitor cells (CPCs: CD34+) and endothelial progenitor cells (EPCs: CD34+KDR+) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients with out diabetes ( n=7),non-proliferative DR (NPDR, n=7),non-proliferative DR (PDR, n=8), and PDR complicated with diabetic nephr opathy (PDR-DN, n=7).Results The numbers of EPOR+ CPCs and EPOR+ EPCs were reduced remarkably in NPDR compared with the control group (both P<0.01), whereas rebounded in PDR and PDR-DN groups in varyingdegrees. Similar changes were observed in respect of the proportion of EPOR+CPCs in CPCs (NPDR vs. control, P<0.01) and that of EPOR+ EPCs in EPCs (NPDR vs. control, P<0.05).Conclusion Exogenous EPO, mediated via the EPO/EPOR system of EPCs, may alleviate the impaired vascular regeneration in NPDR, whereas it might aggravate retinal neovascularization in PDR due to a rebound of EPOR+EPCs associated with ischemia.

Key words: circulating progenitor cells, endothelial progenitor cells, erythropoietin re-ceptor, diabetic retinopathy

Copyright © 2021 Chinese Academy of Medical Sciences.  京公安备110402430088  京ICP备06002729号-1  Powered by Magtech.

Supervised by National Health Commission of the People's Republic of China

9 Dongdan Santiao, Dongcheng district, Beijing, 100730 China

Tel: 86-10-65105897  Fax:86-10-65133074 


Copyright © 2018 Chinese Academy of Medical Sciences

All right reserved.

京公安备110402430088  京ICP备06002729号-1