Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (3): 142-148.doi: 10.1016/S1001-9294(16)30042-6

• Orginal Article • Previous Articles     Next Articles

Short- and Long-term Therapeutic Efficacies of Intravenous Transplantation of Bone Marrow Stem Cells on Cardiac Function in Rats with Acute Myocardial Infarction: A Meta-analysis of Randomized Controlled Trials

Can Jiang, Dong Zheng, Yun-lu Feng, Jun Guo*, Hai-rui Li, Ai-dong Zhang   

  1. Department of Cardiology, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • Online:2016-09-20 Published:2016-09-20
  • Contact: Tel: 86-20-38688620, Fax: 86-20-38688000, E-mail: dr.guojun@163.com
  • Supported by:
    △Supported by the Youth Project of National Natural Science Foundation (81100078) , the Key Project of Chinese Ministry of Education (211207), Guangzhou Pearl River science and technology new star project plan (2012J2200063) and Project of Guangdong Science and Technology Department (S2011040001392)

Abstract: Objective To investigate the short- and long-term therapeutic efficacies of intravenous trans- plantation of bone marrow stem cells (MSCs) in rats with experimental myocardial infarction by meta- analysis. Methods Randomized controlled trials were systematically searched from PubMed, Science Citation Index (SCI), Chinese journal full-text database (CJFD) up to December 2014. While the experimental groups (MSCs groups) were injected MSCs intravenously, the control groups were injected Delubecco’s minimum essential medium (DMEM) or phosphate buffered saline (PBS). Subgroup analysis for each outcome measure was performed for the observing time point after the transplantation of MSCs. Weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated for outcome parameters including ejection fraction (EF) and fractional shortening (FS), which were measured by echocardiogram after intravenous injection and analyzed by RevMan 5.2 and STATA 12.0. Results Data from 9 studies (190 rats) were included in the meta-analysis. As compared to the control groups, the cardiac function of the experimental groups were not improved at day 7 (EF: WMD=0.08, 95%CI -1.32 to 1.16, P>0.01; FS: WMD=-0.12, 95%CI -0.90 to 0.65, P>0.01) until at day 14 after MSCs’ transplantation (EF: WMD=10.79, 95%CI 9.16 to 12.42, P<0.01; FS: WMD=11.34, 95%CI 10.44 to 12.23, P<0.01), and it lasted 4 weeks or more after transplantation of MSCs (EF: WMD=13.94, 95%CI 12.24 to 15.64, P<0.01; FS: WMD=9.64, 95%CI 7.98 to 11.31, P<0.01). Conclusion The therapeutic efficacies of MSCs in rats with myocardid infarction become increasing apparent as time advances since 2 weeks after injection.

Key words: mesenchymal stem cells, rats, myocardial infarction, intravenous

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