Chinese Medical Sciences Journal ›› 2019, Vol. 34 ›› Issue (1): 60-64.doi: 10.24920/003462

• Case Reports • Previous Articles     Next Articles

Successful Treatment of Severe Heparin-induced Thrombocytopenia with Intravenous Immunoglobulin, Platelet Transfusion and Rivaroxaban: A Case Report

Huang He, Lin Ying, Yao Rongxin, He Muqing, Lin Xiaoji()   

  1. Department of Hematology, The 2nd Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
  • Received:2018-05-22 Revised:2019-02-22 Online:2019-03-30 Published:2019-04-08
  • Contact: Lin Xiaoji E-mail:linxiaoji321@163.com
The authors successfully treated a case of severe heparin-induced thrombocytopenia with thrombosis and life-threatening bleeding complications with intravenous immunoglobulin, platelet transfusion and oral anticoagulant Rivaroxaban. They considered that intravenous immunoglobulin played the most important role by preventing further thrombosis, increasing the platelet count, and ensuring the efficacy of Rivaroxaban.

Abstract:

Heparin-induced thrombocytopenia (HIT) is a relatively infrequent complication of heparin administration. HIT can cause devastating thrombosis, making it one of the most serious adverse drug reactions encountered in clinical practice. We successfully treated a case of severe HIT presenting with thrombosis and life-threatening bleeding complications with intravenous immunoglobulin (IVIG), platelet transfusion and oral anticoagulant Rivaroxaban. In this case, we considered that IVIG played the most important role by preventing further thrombosis, increasing the platelet count, and ensuring the efficacy of Rivaroxaban. We therefore suggest that IVIG might be the optimal treatment for patients with this urgent condition.

Key words: heparin-induced thrombocytopenia, thrombosis, intravenous immunoglobulin, platelet transfusion, rivaroxaban

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