Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (2): 130-137.doi: 10.24920/004183
• Original Article • Previous Articles Next Articles
Xu Chen1, Hong-Ling Liu2, Jin-Sui Wang1, Feng-Hui Zhao1, *()
Received:
2022-10-18
Accepted:
2023-04-28
Published:
2023-06-30
Online:
2023-06-08
Contact:
*Primary small cell ovarian cancer of pulmonary type (SCCOPT) is a rare ovarian tumor with a poor prognosis. This study retrospectively summarized the clinical, imaging, laboratory, and pathological characteristics of 6 SCCOPT cases who were pathologically diagnosed at the Gansu Provincial Hospital and of 31 cases reported in literatures. The result revealed that the SCCOPT of all patients showed positive expression of sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX-2), which indicating that SOX-2 could be a biomarker used to diagnose SCCOPT. |
Xu Chen, Hong-Ling Liu, Jin-Sui Wang, Feng-Hui Zhao. Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures[J].Chinese Medical Sciences Journal, 2023, 38(2): 130-137.
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Table 1.
Clinical features and treatment methods of SCCOPT"
References | Age (yrs) | Clinical symptoms | Tumor staging | Tumor diameter (cm) | Operation | Chemotherapy | Overall survival time (months) |
---|---|---|---|---|---|---|---|
Eichhorn et al.[ | 62 | pelvic mass | ⅠA (no metastasis ) | 21.5 | RSO | NR | 4, die from disease |
Eichhorn et al.[ | 59 | pelvic mass | ⅠA (no metastasis) | 17.0 | TAH, RSO | NR | NR |
Eichhorn et al.[ | 55 | pelvic mass | ⅠA (no metastasis) | 26.0 | TAH, BSO | NR | NR |
Eichhorn et al.[ | 30 | abdominal mass | ⅠC (no metastasis) | 20.0 | BSO | NR | 6, die from disease |
Eichhorn et al.[ | 84 | abdominal mass | ⅡB (peritoneal metastasis) | 13.5 | BSO | NR | 1, die from disease |
Eichhorn et al.[ | 76 | vaginal bleeding and pelvic mass | ⅢB (peritoneal metastasis) | NR | TAH, BSO | NR | 12, die from disease |
Eichhorn et al.[ | 50 | vaginal bleeding and abdominal mass | ⅢB (peritoneal metastasis) | NR | TAH, BSO | NR | NR |
Eichhorn et al.[ | 72 | pelvic mass | ⅢB (peritoneal metastasis) | 4.5 | TAH, BSO | cisplatin, cyclophosphamide | NR |
Eichhorn et al.[ | 64 | pelvic mass | ⅢB (peritoneal metastasis) | 5.5 | TAH, BSO | cisplatin, cyclophosphamide | 12, die from disease |
Eichhorn et al.[ | 49 | pelvic mass and ascites | ⅢB (peritoneal metastasis) | 16.0 | LSO | cisplatin, cyclophosphamid, doxorubicin | 8, die from disease |
Eichhorn et al.[ | 46 | abdominal pain and mass | ⅢC (peritoneal metastasis) | 9.5 | TAH, BSO | cisplatin, cyclophosphamide, etoposide | 13, die from disease |
Chang et al.[ | 22 | pelvic mass | ⅢA (peritoneal metastasis ) | 18.0 | TAH, LSO | cisplatin, cyclophosphamide | 19, die from disease |
Fukunaga et al.[ | 60 | abdominal mass | Ⅳ (lung metastasis) | 14.0 | TAH, RSO | cisplatin, cyclophosphamide | 10, die from lung metastasis |
Lim et al.[ | 28 | vaginal bleeding, pelvic mass, and acute abdomen | ⅢB (peritoneal metastasis ) | 20.0 | TAH, RSO | NR | NR |
Mebis et al.[ | 54 | pelvic mass | ⅢA (peritoneal metastasis | 12.0 | TAH, BSO | cisplatin, etoposide | 22, die from disease |
Wang et al.[ | 22 | abdominal mass and ascites | IV (extrapelvic nodal metastasis) | 4.3 | TAH, BSO, LYM, OMT | NR | NR |
Rund et al.[ | 56 | vaginal bleeding and ascites | Ⅳ (liver metastasis) | 12.0 | TAH, RSO | cisplatin, etoposide | 7, die from brain metastasis |
Rund et al.[ | 39 | pelvic mass | ⅢB (peritoneal metastasis) | 15.0 | TAH, BSO | Cisplatin, etoposide, taxol | 16, die from disease |
Marie et al.[ | 32 | abdominal mass and ascites | Ⅳ (lung metastasis) | 20.0 | TAH, BSO | paclitaxel, carbiplatin | 15, die from lung metastasis |
Suzuki et al.[ | 49 | pelvic mass | Ⅳ (liver metastasis) | 15.0 | TAH, BSO | paclitaxel, carbiplatin | 25, die from lung metastasis |
Tsolakidis et al.[ | 55 | abdominal mass and pain | Ⅳ (liver metastasis) | 8.0 | TAH, BSO, LYM | carboplatin, etoposide | 21, die from brain metastasis |
Ikota et al.[ | 65 | abdominal mass and pain | Ⅳ (liver metastasis) | 18.0 | NR | NR | 6, die from brain metastasis |
Kurasaki et al.[ | 54 | pelvic mass | ⅢA (peritoneal metastasis) | 14.0 | TAH, LSO, OMT | paclitaxel | 22, die from disease |
Oyang et al.[ | 56 | abdominal mass and pain | Ⅳ (brain metastasis) | 5.0 | TAH, BSO, LYM, OMT | cispatin, etoposide, | NR |
Rubio et al.[ | 80 | pelvic mass | Ⅳ (liver metastasis) | 20.0 | TAH, BSO | cisplatin, etoposide, paclitaxel | 21, die from lung metastasis |
Hashimoto et al.[ | 75 | abdominal pain and ascites | Ⅳ (lung metastasis) | 12.5 | TAH, BSO, OMT | cisplatin, etoposide | NR |
Kalampokas et al.[ | 77 | pelvic mass | ⅡB (peritoneal metastasis) | 11.3 | TAH, BSO | cyclophosphamide, doxorubicin | NR |
Oneda et al.[ | 72 | abdominal mass and vaginal bleeding | ⅢC (peritoneal metastasis) | 6.0 | TAH, LSO, LYM | carboplatin | 10, die from disease |
Ishikawa et al.[ | 50 | pelvic mass and ascites | Ⅳ (omentum and extrapelvic nodal metastasis) | 12.0 | TAH, LSO, OMT | cisplatin, etoposide, paclitaxel | 12, die from lung metastasis |
Li et al.[ | 45 | abdominal pain and mass | Ⅳ (bone metastasis) | 10.0 | TAH, BSO, OMT, LYM | paclitaxel, etoposide | NR |
Asom et al.[ | 80 | abdominal mass, ascites, and vaginal bleeding | Ⅳ (omentum and extrapelvic nodal metastasis) | 18.5 | TAH, RSO, LYM | carboplatin treatment after radiotherapy | 16, die from lung metastasis |
Case 1 | 65 | pelvic mass and lower abdominal pain | ⅢA (peritoneal metastasis) | 10.7 | TAH, BSO | cisplatin, doxorubicin | 27, die from disease |
Case 2 | 42 | abdominal mass and ascites | Ⅳ (liver metastasis) | 13.6 | TAH, BSO, OMT, LYM, AP | cisplatin, cyclophosphamide | 10, die from brain metastasis |
Case 3 | 53 | abdominal mass and lower abdominal pain | ⅢB (peritoneal metastasis) | 11.2 | TAH, BSO, OMT, LYM | cisplatin, paclictaxel | 16, die from disease |
Case 4 | 79 | pelvic mass and vaginal bleeding | ⅢB (peritoneal metastasis) | 13.4 | TAH, BSO, OMT | carboplatin, paclictaxel | 24, die from disease |
Case 5 | 61 | pelvic mass and ascites | Ⅵ (omentum and lung metastasis) | 15.8 | TAH, BSO, OMT, LYM, AP | carboplatin, etoposide | 9, die from lung metastasis |
Case 6 | 73 | abdominal mass and lower abdominal pain | ⅡA (fallopian tube involvement) | 9.1 | TAH, BSO | cisplatin, paclictaxel | NA |
Figure 2.
Pelvic MRI findings and macroscopic pathology of a 42-year-old woman with SCCOPT (Case 2). (A) The lesion shows a low signal on a T1-weighted image (red arrow). (B) The lesion shows heterogeneously high intensity on T2-weighted image (red arrow). (C, D) The lesion shows contrast enhancement on enhanced MRI scan (red arrows). (E) The lesion appears as a complex cystic and solid mass with a papillary structure."
Figure 3.
Cytological findings of peritoneal effusion with smear test in two patients with SCCOPT. HE stain (A, B) A large number of atypical cells (red arrow) are aggregated together in the peritoneal effusion of Case 2. (C) A mass of tumor cells of Case 5 form some small clusters (red arrows). (D) The tumor cells in peritoneal effusion of Case 5 have a high nucleus-to-cytoplasm ratio with oval-to-round nuclei, fine granular chromatin, scant cytoplasm, and indistinct nucleoli."
Figure 4.
Histological and immunohistochemical results in three patients with SCCOPT. (A, B) HE stains showing the tumor of Case 3 consisted of small cells with scant cytoplasm and mitotic nuclei, and local necrosis (red triangle). (C, D) SCCOPT of Case 6 coexisted with Brenner tumor (red triangle) (HE stain). (E) SCCOPT of Case 4 was positive for wide-spectrum (pan) cytokeratin (DAB stain). (F) SCCOPT of Case 4 was positive for CD56 (DAB stain). (G) SCCOPT of Case 4 was positive for synaptophysin (DAB stain). (H) SCCOPT of Case 4 was negative for chromogranin A (DAB stain). (I) SCCOPT of Case 4 was negative for neuron-specific enolase (DAB stain). (J) Case 4 was negative for thyroid transcription factor-1 (DAB stain). (K) SCCOPT of Case 4 was positive for sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX-2, DAB stain). (L) SCCOPT of Case 4 was negative for somatostatin receptor type 2 (DAB stain)."
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