Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (4): 257-264.doi: 10.24920/004202
• Original Article • Next Articles
Lu Che, Jia-Wen Yu, Yue-Lun Zhang, Li Xu(), Yu-Guang Huang
Received:
2022-12-22
Accepted:
2023-07-12
Published:
2023-12-30
Online:
2023-09-06
Contact:
Li Xu
E-mail:pumchxuli@163.com
Lu Che,Jia-Wen Yu,Yue-Lun Zhang,Li Xu,Yu-Guang Huang. Intraoperative Blood Pressure Lability Acts as a Key Mediator in the Impacts of Goal-Directed Fluid Therapy on Postoperative Complications in Patients Undergoing Major Spine Surgery[J].Chinese Medical Sciences Journal, 2023, 38(4): 257-264.
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Table 1.
Baseline characteristics of the GDFT group and the control group"
Variables | GDFT group (n = 150) | Control group (n = 150) | P value |
---|---|---|---|
Age (yrs, mean ± SD) | 57.8 ± 17.2 | 59.2 ± 13.8 | 0.448 |
Sex, male [n (%)] | 61 (40.7) | 63 (42.0) | 0.725 |
BMI (kg/m2, mean ± SD ) | 25.4 ± 3.8 | 25.4 ± 3.3 | |
ASA score [n (%)] | 0.971 | ||
≤ Ⅱ | 141 (94.0) | 144 (91.0) | |
> Ⅱ | 9 (6.0) | 6 (9.0) | |
Comorbidity [n (%)] | |||
Hypertension | 66 (44.0) | 61 (40.7) | 0.514 |
Coronary artery disease | 10 (6.7) | 10 (6.7) | 0.987 |
Diabetes mellitus type Ⅱ | 21 (14.0) | 25 (16.8) | 0.521 |
Baseline Hb (g·L-1, mean ± SD) | 136.0 ± 13.2 | 134.7 ± 19.4 | 0.486 |
Baseline HR (bpm, mean ± SD) | 77.0 ± 9.2 | 79.0 ± 10.5 | 0.162 |
Baseline SBP (mmHg, mean ± SD) | 129.5 ± 15.9 | 132.3 ± 15.3 | 0.121 |
Baseline creatinine (μg·ml-1, mean ± SD) | 67.9 ± 19.3 | 67.1 ± 12.8 | 0.657 |
Infused crystalloids [ml·kg-1·h-1, median (IQR)] | 7.2 (4.6-9.8) | 7.4 (5.1-9.7) | 0.398 |
Infused colloids [ml·kg-1·h-1, median (IQR)] | 1.6 (0.3-2.9) | 1.6 (0.3-2.9) | 0.893 |
Vasopressor [n (%)] | 7 (4.67) | 20 (13.33) | 0.009 |
Operation time [min, median (IQR)) | 184 (153-220) | 193 (156-225) | 0.404 |
ARV (mmHg·min-1, median (IQR)) | 0.87 (0.53-1.25) | 1.73 (1.16-2.49) | <0.001 |
TWA_MAP (mmHg, mean ± SD) | 82.7 ± 7.7 | 82.3 ± 9.5 | 0.219 |
Table 2.
Results of crude and adjusted analysis of the association with 30-day postoperative complications"
Items | Crude | Adjusted* | |||||
---|---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | ||
GDFT | 0.510 | 0.319, 0.815 | 0.005 | 0.460 | 0.278, 0.761 | 0.003 | |
TWA_MAP | 0.922 | 0.892, 0.953 | <0.001 | 0.928 | 0.897, 0.960 | <0.001 | |
ARV (mmHg·min-1) | 1.687 | 1.338, 2.126 | <0.001 | 1.634 | 1.278, 2.090 | <0.001 |
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