Chinese Medical Sciences Journal ›› 2016, Vol. 31 ›› Issue (1): 17-22.

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Positive Rate of Different Hepatitis B Virus Serological Markers in Peking Union Medical College Hospital, a General Tertiary Hospital in Beijing

Yue-qiu Zhang1, Sai-nan Bian1, Xiao-qing Liu1, 2, *, Shao-xia Xu3, Li-fan Zhang1, 2, Bao-tong Zhou1, Wei-hong Zhang3, Yao Zhang2, Ying-chun Xu3, Guo-hua Deng1   

  1. 1Department of Infectious Diseases,
    2Clinical Epidemiology Unit,
    3Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
  • Received:2015-04-01 Online:2016-03-20 Published:2016-03-20
  • Contact: Tel: 86-10-69155087, Fax: 86-10-69155046, E-mail: liuxqpumch@126.com
  • Supported by:

    △Supported by the Key Project from Beijing Municipal Science and Technology Commission (D121100003912003)

Abstract:

Objective s To investigate the positive rate of different hepatitis B virus (HBV) serological markers, and the demographic factors related to HBV infection.Methods We enrolled all patients tested for HBV serological markers, such as HBV surface antigen (HBsAg), HBV surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb), HBV core antibody (HBcAb), and HBV-DNA from July 2008 to July 2009 in Peking Union Medical College Hospital. The positive rate of each HBV serological marker was calculated according to gender, age, and de- partment, respectively. The positive rates of HBV-DNA among patients with positive HBsAg were also analyzed.Results Among 27 409 samples included, 2681 (9.8%) were HBsAg positive. When patients were divided into 9 age groups, the age-specific positive rate of HBsAg was 1.2%, 9.6%, 12.3%, 10.9%, 10.3%, 9.7%, 8.0%, 5.8%, and 4.3%, respectively. The positive rate of HBsAg in non-surgical department, surgical department, and health examination center was 16.2%,5.8%,and 4.7%, respectively. The positive rate of HBsAg of males (13.3%) was higher than that of females (7.3%, P=0.000). Among the 2681 HBsAg (+) patients, 1230 (45.9%) had HBV-DNA test, of whom 564 (45.9%) were positive. Patients with HBsAg (+), HBeAg (+), and HBcAg (+) result usually had high positive rate of HBV-DNA Results (71.8%, P=0.000).Conclusions Among this group of patients in our hospital, the positive rate of HBsAg was relatively high. Age group of 20-29, males, and patients in non-surgical departments were factors associated with high positive rate of HBsAg.

Key words: hepatitis B virus infection, positive rate, hepatitis B virus serological markers, demographic factors

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