Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (2): 135-149.doi: 10.24920/003729

• 综述 • 上一篇    下一篇

骨质疏松性骨折风险评估的潜在生物分子:一项综述回顾

刘婕妤1,2,3,王嘉祥1,2,3,许力1,2,邓飞艳1,2,*()   

  1. 1苏州大学医学部公共卫生学院遗传流行病学与基因组学,江苏,苏州 215123
    2苏州大学医学部,江苏省老年病预防与转化医学重点实验室,江苏,苏州 215123
    3苏州大学医学部公共卫生学院流行病学与生物统计学教研室,江苏,苏州 215123
  • 收稿日期:2020-09-13 出版日期:2021-06-30 发布日期:2021-07-07
  • 通讯作者: 邓飞艳 E-mail:fdeng@suda.edu.cn

Potential Biomolecules Capable of Assessing Risk of Osteoporotic Fracture: A Scoping Review

Jieyu Liu1,2,3,Jiaxiang Wang1,2,3,Li Xu1,2,Feiyan Deng1,2,*()   

  1. 1Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
    2Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
    3Department of Epidemiology and Biostatics, School of Public Health, Medical College of Soochow University, Jiangsu, Suzhou 215123, China
  • Received:2020-09-13 Published:2021-06-30 Online:2021-07-07
  • Contact: Feiyan Deng E-mail:fdeng@suda.edu.cn

摘要:

骨质疏松症是一种系统性的慢性骨骼疾病,其特征为骨矿密度低、骨质疏松性骨折风险升高。骨质疏松症好发于中老年人群,尤其是绝经后妇女。伴随着人口老龄化,骨质疏松症已成为全球范围内严重的公共卫生问题。尽早识别高危人群、及时有效的干预和治疗对于预防骨质疏松性骨折至关重要。鉴于骨质疏松症的遗传率较高且发病机制复杂,有必要综合考虑重要的生物分子、从而对骨质疏松性骨折进行准确的风险评估。为此,我们总结回顾了可用于骨质疏松性骨折风险评估的潜在生物分子及其最新研究进展。未来对于这些生物分子的系统评估有助于研发新的方法和检测策略,比如开发生物芯片,以应用于骨质疏松症的早期识别和骨质疏松性骨折的预防。

关键词: 骨质疏松性骨折, 分子, 预测, 诊断

Abstract:

Osteoporosis as a systemic chronic skeletal disease is characterized by low bone mineral density and increased risk to osteoporotic fractures. Osteoporosis is prevalent in the middle-aged and elderly population, especially in the postmenopausal women. With population aging, osteoporosis has become a world-wide serious public health problem. Early recognition of the high-risk population followed by timely and efficient intervention and/or treatment is important for preventing osteoporotic fractures. In light of the high heritability and complex pathogenesis of osteoporosis, comprehensive consideration of vital biological/biochemical factors is necessary for accurate risk evaluation of fractures. For this purpose, we review recent research progress on molecules which can be applied to assess risk for osteoporotic fractures. Future integrative analyses and systematic evaluation of these molecules may facilitate developing novel methodologies and/or test strategies, i.e., biochips, for early recognition of osteoporosis, hence contributing to preventing osteoporotic fractures.

Key words: osteoporotic fracture, molecules, predictive, diagnostic

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