视神经炎患者视神经磁共振成像直方图分析

doi:10.24920/003507

Abstract

Objective To evaluate the optic nerve impairment using MRI histogram texture analysis in the patients with optic neuritis.

Methods The study included 60 patients with optic neuritis and 20 normal controls. The coronal T2 weighted imaging (T2WI) with fat saturation and enhanced T1 weighted imaging (T1WI) were performed to evaluate the optic nerve. MRI histogram texture features of the involved optic nerve were measured on the corresponding coronal T2WI images. The normal optic nerve (NON) was measured in the posterior 1/3 parts of the optic nerve. Kruskal-Wallis one-way ANOVA was used to compare the difference of texture features and receiver operating characteristic (ROC) curve were performed to evaluate the diagnostic value of texture features for the optic nerve impairment among the affected optic nerve with enhancement (ONwEN), affected optic nerve without enhancement (ONwoEN), contralateral normal appearing optic nerve (NAON) and NON.

Results The histogram texture Energy and Entropy presented significant differences for ONwEN vs. ONwoEN (both P=0.000), ONwEN vs. NON (both P=0.000) and NAON vs. NON (both P<0.05). ROC analysis demonstrated that the area under the curve (AUC) of histogram texture Energy were 0.758, 0.795 and 0.701 for ONwEN vs. ONwoEN, ONwEN vs. NON and NAON vs. NON, AUC of Entropy were 0.758, 0.795 and 0.707 for ONwEN vs. ONwoEN, ONwEN vs. NON and NAON vs. NON.

Conclusion The altered MRI histogram texture Energy and Entropy could be considered as a surrogate for MRI enhancement to evaluate the involved optic nerve and normal-appearing optic nerve in optic neuritis.

Key words: histogram analysis, optic nerve, optic neuritis, texture analysis, Energy, Entropy

Liu Hongjuan, Zhou Huanfen, Zong Linxiong, Liu Mengqi, Wei Shihui, Chen Zhiye. MRI Histogram Texture Feature Analysis of the Optic Nerve in the Patients with Optic Neuritis[J].Chinese Medical Sciences Journal, 2019, 34(1): 18-23.

Figures/Tables 5

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Table 1

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Figure 2.

References 12.

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Groups	n	Skewness	Kurtosis	Uniformity	Energy	Entropy
ONwEN	41	0.205 (-0.45,1.50)	-0.410 (-1.32,1.95)	0.908 (0.81,0.96)	0.026 (0.02,0.14)	5.220 (2.95,6.02)
ONwoEN	45	0.226 (-0.58,1.21)	-0.677 (-1.63,1.92)	0.906 (0.73,0.98)	0.050 (0.02,0.22)	4.404 (2.25,5.75)
NAON	34	0.076 (-0.54,1.66)	-0.597 (-1.27,3.59)	0.888 (0.71,0.96)	0.031 (0.02,0.16)	5.065 (2.75,5.94)
NON	40	0.079 (-0.80,1.00)	-0.664 (-1.83,0.16)	0.909 (0.68,0.96)	0.058 (0.02,0.22)	4.175 (2.25,6.06)
H value		1.833	4.037	2.154	28.031	28.384
P value		0.608	0.257	0.541	<0.001	<0.001

Items	Energy		Entropy
Items	H value	P value	H value	P value
ONwEN vs. NAON	13.321	1.000	13.159	1.000
ONwEN vs. ONwoEN	40.328	0.000	40.512	0.000
ONwEN vs. NON	47.064	0.000	47.287	0.000
NAON vs. ONwoEN	27.007	0.062	27.353	0.056
NAON vs. NON	33.743	0.011	34.128	0.010
ONwoEN vs. NON	6.736	1.000	6.775	1.000

Items	Energy					Entropy					Z value	P value
Items	AUC	95%CI	Sensitivity (%)	Specificity (%)	Cut-off value	AUC	95%CI	Sensitivity (%)	Specificity (%)	Cut-off value	Z value	P value
ONwEN vs. ONwoEN	0.758	0.654-0.844	78.0	66.7	0.040	0.758	0.653-0.844	78.0	66.7	4.681	0.097	0.923
ONwEN vs. NON	0.795	0.690-0.876	58.5	92.5	0.030	0.795	0.691-0.877	61.0	92.5	5.101	0.143	0.887
NAON vs. NON	0.701	0.584-0.802	52.9	85.0	0.031	0.707	0.590-0.807	64.7	75.0	4.79	1.271	0.204

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