Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (1): 85-91.doi: 10.24920/003532
• Original Article • Previous Articles Next Articles
Yin Ying1, Li Rui2, Li Xiaoli2, Wu Kunrong2, Li Ling2, Xu Yuedong4, Liao Lin4, Yang Rui3, Li Yan3, *()
Received:
2019-05-12
Published:
2020-03-31
Online:
2020-04-16
Contact:
Li Yan
E-mail:li_xyan@126.com
Yin Ying, Li Rui, Li Xiaoli, Wu Kunrong, Li Ling, Xu Yuedong, Liao Lin, Yang Rui, Li Yan. Association Between Homocysteine Level and Methylenetetrahydrofolate Reductase Gene Polymorphisms in Type 2 Diabetes Accompanied by Dyslipidemia[J].Chinese Medical Sciences Journal, 2020, 35(1): 85-91.
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Table 1
Comparisons of clinical and biochemical parameters between T2DM patients with and without dyslipidemia§"
Groups | n | Age (rs) | Height (m) | Weight (kg) | BMI (kg/m2) | Disease duration(rs) | HbA1c (%) | TC (mmol/L) | TG (mmol/L) | LDL-C (mmol/L) | HDL-C (mmol/L) | tHcy (μmol/L) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
T2DM without dyslipidemia | 94 | 59.6± 10.34 | 1.68± 0.08 | 69.38± 10.58 | 24.62± 3.27 | 11.41± 8.21 | 8.37± 1.83 | 4.05± 0.64 | 0.97± 0.33 | 2.23± 0.56 | 1.34± 0.24 | 12.57± 5.50 |
T2DM with dyslipidemia | 82 | 59.72± 9.94 | 1.68± 0.07 | 72.99± 11.10 | 25.89± 3.21 | 9.40± 7.60 | 8.00± 1.57 | 4.62± 1.31 | 1.67± 0.95 | 2.71± 0.92 | 1.14± 0.35 | 12.22± 5.60 |
t value | -0.07 | 0.31 | -2.21 | -2.58 | 1.67 | 1.43 | -3.78 | -6.70 | -4.27 | 4.51 | 0.42 | |
P value | 0.94 | 0.76 | 0.03 | 0.01 | 1.00 | 0.15 | <0.05 | <0.05 | <0.05 | <0.05 | 0.68 |
Figure 1.
Peak map of direct sequencing of MTHFR C677T and A1298C by using dideoxy-mediated chain-termination method. Figures A, B and C showing the peak map of MTHFR C677T CC, CT and TT, respectively, and Figures E, F and G showing the peak map of MTHFR A1298C AA, AC and CC, respectively. MTHFR: methylenetetrahydrofolate redutase."
Table 2
Genotype and allele frequencies of MTHFR C677T and A1298C polymorphisms in T2DM subjects with or without dyslipidemia [n of cases (%)]"
Groups | n | MTHFR C677T genotype | MTHFR C677T allele | MTHFR A1298C genotype | MTHFR A1298C allele | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | CT | TT | C | T | AA | AC+CC | A | C | |||||
T2DM without dyslipidemia | 94 | 12(12.77) | 43(45.74) | 39(41.49) | 67(35.64) | 121(64.36) | 65(69.15) | 29(30.85) | 159(84.57) | 29(15.43) | |||
T2DM with dyslipidemia | 82 | 6(7.32) | 37(45.12) | 39(47.56) | 49(29.88) | 115(70.12) | 62(75.61) | 20(24.39) | 143(87.20) | 21(12.80) | |||
χ2 | 1.46 | 0.01 | 0.65 | 1.32 | 0.91 | 0.49 | |||||||
P | 0.32 | 1.00 | 0.45 | 0.26 | 0.40 | 0.54 |
Table 3
Comparisons of tHcy levels of T2DM patients who carried the different genotypes§ (μmol/L)"
Groups | n | MTHFR C677T | t | P | MTHFR A1298C | t | P | ||
---|---|---|---|---|---|---|---|---|---|
TT | CT+CC | AA | AC+CC | ||||||
All the subjects | 176 | 13.48±6.48 | 11.56±4.52 | 2.27 | 0.02 | 12.47±5.80 | 12.24±4.86 | 0.24 | 0.81 |
T2DM with dyslipidemia | 82 | 13.62±6.97 | 10.95±3.62 | 2.20 | 0.03 | 12.34±6.1 | 11.86±3.51 | 0.33 | 0.74 |
T2DM without dyslipidemia | 94 | 13.34±6.03 | 12.04±5.09 | 1.08 | 0.29 | 12.60±5.48 | 12.50±5.65 | 0.06 | 0.95 |
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