Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (4): 357-365.doi: 10.24920/003659

• 综述 • 上一篇    下一篇

Wnt5a在肿瘤进展中的作用具有争议性

陈旭1,刘红玲2,赵凤辉1,*(),焦宗宪3,王金穗1,党雅梅1   

  1. 1甘肃省人民医院病理科,兰州 730000,中国
    2甘肃省第三人民医院职业病科,兰州 730000,中国
    3兰州大学基础医学院病理学教研室,兰州 730000,中国
  • 收稿日期:2019-09-12 接受日期:2020-02-04 出版日期:2020-12-31 发布日期:2020-10-28
  • 通讯作者: 赵凤辉 E-mail:zhaofh0931@163.com

Wnt5a Plays Controversial Roles in Cancer Progression

Xu Chen1,Hongling Liu2,Fenghui Zhao1,*(),Zongxian Jiao3,Jinsui Wang1,Yamei Dang1   

  1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
    2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
    3Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China
  • Received:2019-09-12 Accepted:2020-02-04 Published:2020-12-31 Online:2020-10-28
  • Contact: Fenghui Zhao E-mail:zhaofh0931@163.com

摘要:

Wnt5a是Wnt家族中一种具有代表性的分子,它通过Wnt非经典途径调控多种细胞功能。虽然Wnt5a在多种病理状态中均有涉及,但其在肿瘤中的作用尚不明确。Wnt5a在肿瘤的作用机制中可能涉及甲基化修饰、不同的mRNA亚型以及调控不同的下游通路。因此,Wnt5a在肿瘤发展起重要作用(侵袭、迁移、增殖、以及上皮-间质转化),是一个潜在的预后和治疗的生物标志物。

关键词: Wnt5a, 肿瘤, 甲基化修饰

Abstract:

Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. Therefore, it is an essential factor in cancers’ progression (invasion, migration, proliferation, and epithelial-mesenchymal transition), and a potential biomarker for prognosis and treatment.

Key words: Wnt5a, cancer, methyl modification

补充说明: 甘肃省卫生行业科研计划项目基金(项目编号:GSWSKY2018-34)

基金资助: 甘肃省卫生行业科研计划项目基金(GSWSKY2018-34)

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