Chinese Medical Sciences Journal ›› 2015, Vol. 30 ›› Issue (3): 179-188.doi: 10.1016/S1001-9294(15)30044-4

• REVIEW • Previous Articles     Next Articles

Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

Yong-qiang Yu1*†, Huai-an Yang2*†, Ming Xiao4*†, Jing-wei Wang4, Dong-yan Huang5, Yagesh Bhambhani1, Lyn Sonnenberg6, Brenda Clark6, Yuan-zhe Jin7, Wei-neng Fu8, Jie Zhang9, Qian Yu10, Xue-ting Liang11, Ming Zhang1, 12, 13   

  1. 1 Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine,;
    4 Department of Obstetrics and Gynecology,;
    12 Department of Surgery-Otolaryngology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada;
    2 Department of Otolaryngology, The First Affiliated Hospital,;
    8 Department of Medical Genetics,;
    9 Department of Biochemistry,;
    11 Department of Medical Imageology, China Medical University, Shenyang 110001, China;
    3 Department of Surgery, The People’s Hospital of Liaoning Province, Shenyang 110016, China;
    5 Department of Otolaryngology-Head & Neck Surgery,PLA General Hospital, Beijing 100853, China; 6Department of Developmental Pediatrics,;
    13 Department of Audiology, Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada;
    7 Department of Cardiology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China;
    10 School of Business, University of Alberta, Edmonton, AB T6G 2G4, Canada
  • Published:2015-10-02 Online:2015-10-02
  • Contact: *Corresponding author Tel: 1-780-2365888, E-mail:

In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibilityin noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

Key words: inherited hearing loss, inheritance, noise-induced hearing loss, genetic susceptibility, gene therapy, stem cell

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