Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (1): 50-56.doi: 10.24920/003711
• Original Article • Previous Articles Next Articles
Honglin Zu1, Likun Hou1, Hongwei Liu2, Yuanbo Zhan3, Ju He1, *()
Received:
2020-01-08
Accepted:
2020-05-23
Published:
2021-03-17
Online:
2021-03-17
Contact:
Ju He
E-mail:hejutian@163.com
Honglin Zu,Likun Hou,Hongwei Liu,Yuanbo Zhan,Ju He. Identify Candidate Genes in the Interaction between Abdominal Aortic Aneurysm and Type 2 Diabetes Mellitus by Using Biomedical Discovery Support System[J].Chinese Medical Sciences Journal, 2021, 36(1): 50-56.
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Figure 1.
Closed discovery process in the BITOLA system. The search process starts simultaneously from AAA and DM, resulting in overlapping Gn. The dashed arrows indicate potentially interesting “gene or gene product” of discovery; the solid arrows indicate unsuccessful “gene or gene product”. AAA, abdominal aortic aneurysm; DM, diabetes mellitus."
Table 1
Differentially expressed genes of the abdominal aortic aneurysm and diabetes mellitus based on microarray platforms."
Disease | Series | Tissue | Subjects | Array platform | Overlap with CIM | |
---|---|---|---|---|---|---|
Control | study | |||||
Abdominal Aortic Aneurysm | GSE7084 | Human abdominal aorta | 2 | 2 | Affymetrix | ISG20, ITGAX, DSTN, CCL5, CCR5, AGTR1, CD19, CD44 |
GSE57691 | Human abdominal aorta | 10 | 49 | Illumina | None | |
GSE47472 | Full thickness aorta biopsy | 8 | 14 | Illumina | None | |
Diabetes Mellitus | GSE13760 | Arterial intima-media | 11 | 10 | Affymetrix | PSMD12, FAS |
Figure 2.
Human Electronic Fluorescent Pictograph browser output showing high expressions of PSMD12 in both aorta and pancreatic tissues. (A) “Anatogram” and (C) histogram of PSMD12 expressions by the data source of “circulatory-respiratory” system. (B) “Anatogram” and (D) histogram of PSMD 12 expressions by the data source of “skeletal-immune-digestive” system."
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