Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (1): 50-56.doi: 10.24920/003711

• Original Article • Previous Articles     Next Articles

Identify Candidate Genes in the Interaction between Abdominal Aortic Aneurysm and Type 2 Diabetes Mellitus by Using Biomedical Discovery Support System

Honglin Zu1, Likun Hou1, Hongwei Liu2, Yuanbo Zhan3, Ju He1, *()   

  1. 1Department of Vascular Surgery, Tian Jin First Center Hospital, Tianjin 300192, China
    2Department of Vascular Surgery, 3Department of Periodontology and Oral Mucosa; the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
    3Department of Periodontology and Oral Mucosa; the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China
  • Received:2020-01-08 Accepted:2020-05-23 Published:2021-03-17 Online:2021-03-17
  • Contact: Ju He

Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm (AAA) and type 2 diabetes mellitus (DM).

Methods We used the Biomedical Discovery Support System (BITOLA) to screen out the candidate intermediate molecular (CIM) “Gene or Gene Product” that are related to AAA and DM. The dataset of GSE13760, GSE7084, GSE57691, GSE47472 were used to analyze the differentially expressed genes (DEGs) of AAA and DM compared to the healthy status. We used the online tool of Venny 2.1 assisted by manual checking to identify the overlapped DEGs with the CIMs. The Human eFP Browser was applied to examine the tissue specific expression levels of the detected genes in order to recognize strong expressed genes in both human artery and pancreatic tissue.

Results There were 86 CIMs suggested by the closed BITOLA system. Among all the DEGs of AAA and DM, 8 genes in GSE7084 (ISG20, ITGAX, DSTN, CCL5, CCR5, AGTR1, CD19, CD44) and 2 genes in GSE13760 (PSMD12, FAS) were found to be overlapped with the 86 CIMs. By manual checking and comparing with tissue-specific gene data through Human eFP Browser, the gene PSMD12 (proteasome 26S subunit, non-ATPase 12) was recognized to be strongly expressed in both the aorta and pancreatic tissue.

Conclusion We proposed a hypothesis through text mining that PSMD12 might be involved or potentially involved in the interconnection between AAA and DM, which may provide a new clue for studies on novel therapeutic strategies for the two diseases.

Key words: abdominal aortic aneurysm, diabetes mellitus, Biomedical Discovery Support System, text mining, gene expression profile

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