Chinese Medical Sciences Journal ›› 2018, Vol. 33 ›› Issue (1): 38-44.doi: 10.24920/11803

• Original Article • Previous Articles     Next Articles

Reliability of Three Dimentional Pseudo-continuous Arterial Spin Labeling: A Volumetric Cerebral Perfusion Imaging with Different Post-labeling Time and Functional State in Health Adults

Liu Mengqi1, 2, Chen Zhiye1, 2, Ma Lin2, *()   

  1. 1Department of Radiology, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya 572013, China;
    2Department of Radiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China;
  • Received:2017-06-12 Online:2018-03-30 Published:2018-04-05
  • Contact: Ma Lin E-mail:cjr.malin@vip.163.com
  • Supported by:
    Supported by the Foundation for Medical and Health Sci & Tech Innovation Project of Sanya(2016YW37);the Special Financial Grant from China Postdoctoral Science Foundation(2014T70960)

Abstract: Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D pc-ASL) in measuring cerebral blood flow (CBF) with different post-labeling delay time (PLD) in the resting state and the right finger taping state.Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time (PLD) 1.5 seconds and 2.0 seconds in the resting state and the right finger taping state respectively. CBF mapping was calculated and CBF value of both the gray matter (GM) and white matter (WM) was automatically extracted. The reliability was evaluated using the intraclass correlation coefficient (ICC) and Bland and Altman plot.Results ICC of the GM (0.84) and WM (0.92) was lower at PLD 1.5 seconds than that (GM, 0.88; WM, 0.94) at PLD 2.0 seconds in the resting state, and ICC of GM (0.88) was higher in the right finger taping state than that in the resting state at PLD 1.5 seconds. ICC of the GM and WM was 0.71 and 0.78 for PLD 1.5 seconds and PLD 2.0 seconds in the resting state at the first scan, and ICC of the GM and WM was 0.83 and 0.79 at the second scan, respectively.Conclusion This work demonstrated that 3D pc-ASL might be a reliable imaging technique to measure CBF over the whole brain at different PLD in the resting state or controlled state.

Key words: pseudo-continuous arterial spin labeling, magnetic resonance imaging, intraclass correlation coefficient, reliability

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