Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (3): 242-249.doi: 10.24920/004219
• Review • Previous Articles Next Articles
Ke-Qiong Yan, Qi-Si Wu*(), Jun Yang*()
Received:
2023-02-27
Accepted:
2023-05-16
Published:
2023-09-30
Online:
2023-06-09
Contact:
* Qi-Si Wu, E-mail: Ke-Qiong Yan, Qi-Si Wu, Jun Yang. Blood Pressure Variability May Be a New Predictor for the Occurrence and Prognosis of Ischemic Stroke[J].Chinese Medical Sciences Journal, 2023, 38(3): 242-249.
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Figure 1.
Factors affecting blood pressure variability (BPV). BPV is influenced by various factors including neural response, humoral factors, physiology, diseases, drugs, and lifestyle. The fluctuations in BPV reflect individual physiological and psychological changes and can guide precise clinical interventions. RAAS: remin-angiotensin-aldosterone system."
Figure 3.
The possible impacts of blood pressure variability (BPV) on the pathogenesis of ischemic stroke (IS). The fluctuations in BPV affect the pathogenesis of IS through various mechanisms including vascular endothelial injury, humoral regulation, and inflammatory reaction. Each theory emphasizes that an increase in BPV leads to the formation of arterial plaque and arterial stenosis through a series of mechanisms, eventually leading to IS."
Table 1.
Summary of studies on the effect of BPV on the outcome of ischemic stroke"
Author citation | Size (n) | BPV measures | Findings |
---|---|---|---|
Minhas et al. [ | 11,093 | CV | SBPV was significantly associated with poor outcomes in IS patients. |
Kang et al. [ | 4,415 | SD | For patients with IS, BPV but not mean BP increased the 1-year risk of major vascular events. |
Chung et al. [ | 1,161 | SD, CV | BPV was significantly associated with worse neurologic outcomes after IS. |
Dai et al. [ | 2,325 | CV | IS recurrence was associated with both SBPV and DBPV. |
Naito et al. [ | 626 | SD, CV | The SD of SBP and DBP, CV of DBP, and morning BP surge were associated with poor outcomes for IS. |
Zhang et al. [ | 592 | SD, CV | SBPV was a critical predictor for short-term outcomes among patients with IS. |
Martins et al. [ | 674 | SD | SBPV showed an association with 3-month clinical outcome for IS. |
Geng et al. [ | 704 | SD, CV | SBPV was the strongest independent predictor of functional outcomes in IS patients. |
de Havenon et al. [ | 1,891 | SD, CV | Increased SBPV was associated with worse neurologic outcome after IS. |
Kamieniarz-Medrygal et al. [ | 174 | SD | In the acute phase of IS, the SD of BPV was robustly associated with 30-day outcomes. |
Yong et al. [ | 615 | Successive variation in the BP profile | DBPV was an independent predictor of outcomes in IS patients. |
Yamamoto et al. [ | 105 | [(mean daytime BP?mean nighttime BP)/average BP for 24 hours]×100% | Non-dipper BP had an adverse effect on the risk of recurrent IS and poor outcomes. |
Dai et al. [ | 52,387 | CV | Visit-to-visit BPV was associated with the mortality rate of cerebrovascular disease. |
Fukuda et al. [ | 2,566 | SD | Day-by-day BPV was associated with the 3-month functional outcome after acute IS. |
Yang et al. [ | 367 | SD, CV | Increased day-by-day SBPV or DBPV in the IS was associated with a higher risk for unfavorable outcome at 3 months, independent of mean BP levels. |
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