应用BITOLA系统筛选腹主动脉瘤与2型糖尿病相互作用的候选基因

doi:10.24920/003711

Abstract

Objective To explore the candidate genes that play significant roles in the interconnection between abdominal aortic aneurysm (AAA) and type 2 diabetes mellitus (DM).

Methods We used the Biomedical Discovery Support System (BITOLA) to screen out the candidate intermediate molecular (CIM) “Gene or Gene Product” that are related to AAA and DM. The dataset of GSE13760, GSE7084, GSE57691, GSE47472 were used to analyze the differentially expressed genes (DEGs) of AAA and DM compared to the healthy status. We used the online tool of Venny 2.1 assisted by manual checking to identify the overlapped DEGs with the CIMs. The Human eFP Browser was applied to examine the tissue specific expression levels of the detected genes in order to recognize strong expressed genes in both human artery and pancreatic tissue.

Results There were 86 CIMs suggested by the closed BITOLA system. Among all the DEGs of AAA and DM, 8 genes in GSE7084 (ISG20, ITGAX, DSTN, CCL5, CCR5, AGTR1, CD19, CD44) and 2 genes in GSE13760 (PSMD12, FAS) were found to be overlapped with the 86 CIMs. By manual checking and comparing with tissue-specific gene data through Human eFP Browser, the gene PSMD12 (proteasome 26S subunit, non-ATPase 12) was recognized to be strongly expressed in both the aorta and pancreatic tissue.

Conclusion We proposed a hypothesis through text mining that PSMD12 might be involved or potentially involved in the interconnection between AAA and DM, which may provide a new clue for studies on novel therapeutic strategies for the two diseases.

Key words: abdominal aortic aneurysm, diabetes mellitus, Biomedical Discovery Support System, text mining, gene expression profile

Honglin Zu,Likun Hou,Hongwei Liu,Yuanbo Zhan,Ju He. Identify Candidate Genes in the Interaction between Abdominal Aortic Aneurysm and Type 2 Diabetes Mellitus by Using Biomedical Discovery Support System[J].Chinese Medical Sciences Journal, 2021, 36(1): 50-56.

Figures/Tables 3

Figure 1.

Table 1

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Disease	Series	Tissue	Subjects		Array platform	Overlap with CIM
Disease	Series	Tissue	Control	study	Array platform	Overlap with CIM
Abdominal Aortic Aneurysm	GSE7084	Human abdominal aorta	2	2	Affymetrix	ISG20, ITGAX, DSTN, CCL5, CCR5, AGTR1, CD19, CD44
	GSE57691	Human abdominal aorta	10	49	Illumina	None
	GSE47472	Full thickness aorta biopsy	8	14	Illumina	None
Diabetes Mellitus	GSE13760	Arterial intima-media	11	10	Affymetrix	PSMD12, FAS

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Identify Candidate Genes in the Interaction between Abdominal Aortic Aneurysm and Type 2 Diabetes Mellitus by Using Biomedical Discovery Support System

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