Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (1): 23-30.doi: 10.24920/003982

• 论著 • 上一篇    下一篇



  1. 1伊朗医科大学外科系,德黑兰,伊朗
  • 收稿日期:2021-08-14 接受日期:2021-10-15 出版日期:2022-03-31 发布日期:2022-03-07
  • 通讯作者: 阿米尔穆罕默德•梅拉吉哈

Magnetic Resonance Imaging Findings of Olfactory Bulb in Anosmic Patients with COVID-19: A Systematic Review

Atefeh Beigi-khoozani1,Amirmohammad Merajikhah2,*(),Mahdieh Soleimani3   

  1. 1Department of Operating Room, Iran University of Medical Sciences, Tehran, Iran
    2Department of Operating Room, Sabzevar University of Medical Sciences, Razavi Khorasan, Iran
    3Department of Operating Room, Maragheh University of Medical Sciences, East Azerbaijan, Iran
  • Received:2021-08-14 Accepted:2021-10-15 Published:2022-03-31 Online:2022-03-07
  • Contact: Amirmohammad Merajikhah


背景 嗅觉缺失是新冠病毒(SARS-CoV-2)感染者的症状之一。在嗅觉缺失患者中,SARS-CoV-2可暂时改变嗅觉神经细胞和嗅球(OB)的信号传导过程,最终损害嗅觉上皮的结构,导致嗅觉通道的永久性紊乱。这种受损结构可在磁共振成像(MRI)中显示。
方法 两名研究人员独立搜索了四个数据库,包括PubMed、ProQuest、Scopus和Web of Science,以检索截至2020年11月11日的相关记录。检索不限时间、空间和语言。同时也检索了Google Scholar,但仅限于2020年的数据。根据PRISMA流程图对所有发现的文章进行了系统综述。定性研究、病例报告、社论、读者来信和其他非原创研究被排除在本系统分析之外。
结果 初步检索出434条记录。在查阅了标题和摘要后,选出74篇文章;最后,对8篇文章进行了全文审阅。结果显示在新冠肺炎患者可见嗅裂(OC)宽度和体积增加、OC完全或部分破坏以及OC完全阻塞。OB存在明显的变形和退化,并有细微的不对称。在这些研究中,计算机断层扫描(CT)、MRI和正电子发射断层扫描(PET)用于检测嗅觉缺失的结果。
结论 新冠肺炎患者OC的变化大于OB,主要是由于OC的炎症反应和免疫反应。然而,由神经或血管疾病所致的OB变化较少见。局部类固醇治疗和局部生理盐水可能有益。

关键词: 磁共振成像, 嗅球, 新冠肺炎, 嗅觉缺失


Background Anosmia is one of the symptoms in individuals with SARS-CoV-2 infection. In anosmic patients, SARS-CoV-2 temporarily alters the signaling process in olfactory nerve cells and olfactory bulb (OB), which eventually damages the structure of the olfactory epithelium, leading to a permanent disorder in the olfactory pathway that this damaged structure is showed in MRI imaging
Method Two investigators independently searched four databases consisting of PubMed, ProQuest, Scopus, and Web of Science for relevant records as of November 11, 2020 with no time, space, and language restrictions. Google Scholar was also searched for the related resources within the time limit of 2020. All the found articles were reviewed based on the PRISMA flow diagram. Qualitative studies, case reports, editorials, letters, and other non-original studies were excluded from this systematic analysis.
Results Initial search yielded 434 records. After reviewing the titles and abstracts, we selected 74 articles; finally, 8 articles were depicted to be investigated and read in full text. The obtained results showed an increase in the width and volume of the olfactory cleft (OC), complete or partial destruction of OC, and complete occlusion of OC in COVID-19 patients. Deformation and degeneration as well as a subtle asymmetry were evident in the OBs. Computed tomography (CT), meganetic resonance imaging (MRI), and positron emission tomography (PET) were used to detect the outcomes of anosmia in these studies.
Conclusions The changes in OC are greater than those in OB in patients with COVID-19, mainly due to the inflammatory and immune responses in OC. However, fewer changes in OB are due to neurological or vascular disorders. Topical steroid therapy and topical saline can be helpful.

Key words: magnetic resonance imaging, olfactory bulb, COVID-19, anosmia

Copyright © 2018 Chinese Academy of Medical Sciences. All right reserved.
京公安备110402430088 京ICP备06002729号-1  Powered by Magtech.

Supervised by National Health Commission of the People's Republic of China

9 Dongdan Santiao, Dongcheng district, Beijing, 100730 China

Tel: 86-10-65105897  Fax:86-10-65133074 


Copyright © 2018 Chinese Academy of Medical Sciences

All right reserved.

京公安备110402430088  京ICP备06002729号-1