Chinese Medical Sciences Journal ›› 2021, Vol. 36 ›› Issue (2): 110-119.doi: 10.24920/003794
徐佳1,王萱1,*(),金征宇1,*(
),王勤1,游燕2,王士阗1,钱天翼3,薛华丹1
收稿日期:
2020-09-15
出版日期:
2021-06-30
通讯作者:
王萱,金征宇
E-mail:dr_wangxuan@163.com;jinzy@pumch.cn
Jia Xu1,Xuan Wang1,*(),Zhengyu Jin1,*(
),Qin Wang1,Yan You2,Shitian Wang1,Tianyi Qian3,Huadan Xue1
Received:
2020-09-15
Published:
2021-06-30
Contact:
Xuan Wang,Zhengyu Jin
E-mail:dr_wangxuan@163.com;jinzy@pumch.cn
摘要:
目的 探索延长成像时间的钆赛酸二钠(Gd-EOB-DTPA)增强磁共振T1 mapping成像及快速动态增强扫描序列(DCE)、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价是否存在潜在价值。
方法 40只雄性SD大鼠,分为采用四氯化碳溶液腹腔注射的肝功能损伤组[四氯化碳溶液分别注射4周(n=14)、8周(n=8)、12周(n=8)]以及对照组(n=10)。钆赛酸二钠磁共振增强扫描序列包括T1-mapping成像(延至注射对比剂后50分钟)、DCE、以及多期肝胆期成像。测量获得吲哚菁绿15分钟潴留率(ICG R15)。图像分析计算获得影像学参数如T1弛豫时间减低率(ΔT1)、ΔT1减半时间(TΔT1 1/2)、相对强化率(RE)、RE达峰时间(Tmax)、灌注参数等。应用Pearson相关性分析比较影像学参数与ICG R15的关系。
结果30、40、50分钟的ΔT1和ICG R15具有显著正相关性(r=0.784,0.653,0.757,P=0.007,0.041,0.030)。TΔT1 1/2与ICG R15具有显著正相关性(r=0.685,P=0.029)。Tmax与ICG R15具有显著正相关性(r=0.532,P=0.019)。
结论 晚期肝胆期的ΔT1及TΔT1 1/2与肝功能具有中度相关性。延长成像时间的钆赛酸二钠增强磁共振T1 mapping成像及DCE、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价具有一定价值。
Jia Xu, Xuan Wang, Zhengyu Jin, Qin Wang, Yan You, Shitian Wang, Tianyi Qian, Huadan Xue. Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help[J].Chinese Medical Sciences Journal, 2021, 36(2): 110-119.
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