探索应用延长至50分钟的钆赛酸二钠增强磁共振T1 Maps评价大鼠肝纤维化模型肝功能的价值：延长的肝胆期可能提供帮助

doi:10.24920/003794

摘要/Abstract

摘要：

目的探索延长成像时间的钆赛酸二钠（Gd-EOB-DTPA）增强磁共振T1 mapping成像及快速动态增强扫描序列（DCE）、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价是否存在潜在价值。
方法 40只雄性SD大鼠,分为采用四氯化碳溶液腹腔注射的肝功能损伤组[四氯化碳溶液分别注射4周（n=14）、8周（n=8）、12周（n=8）]以及对照组（n=10）。钆赛酸二钠磁共振增强扫描序列包括T1-mapping成像（延至注射对比剂后50分钟）、DCE、以及多期肝胆期成像。测量获得吲哚菁绿15分钟潴留率（ICG R15）。图像分析计算获得影像学参数如T1弛豫时间减低率（ΔT1）、ΔT1减半时间（T_{ΔT1 1/2}）、相对强化率（RE）、RE达峰时间（T_max）、灌注参数等。应用Pearson相关性分析比较影像学参数与ICG R15的关系。
结果30、40、50分钟的ΔT1和ICG R15具有显著正相关性（r=0.784,0.653,0.757,P=0.007,0.041,0.030）。T_{ΔT1 1/2}与ICG R15具有显著正相关性（r=0.685,P=0.029）。T_max与ICG R15具有显著正相关性（r=0.532,P=0.019）。
结论晚期肝胆期的ΔT1及T_{ΔT1 1/2}与肝功能具有中度相关性。延长成像时间的钆赛酸二钠增强磁共振T1 mapping成像及DCE、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价具有一定价值。

关键词: 肝功能, T1 mapping, 钆赛酸二钠, 磁共振成像

Abstract:

Objectives To investigate whether a longer time period of gadolinium ethoxybenzyl diethylenetriaminepen-taacetic acid (Gd-EOB-DTPA)-enhanced T1 mapping scanning, as well as dynamic contrast-enhanced (DCE) and multiple hepatobiliary phase magnetic resonance imaging (MRI) have the potential to provide information about liver function in rats with liver fibrosis.
Methods Forty rats were divided into the carbon tetrachloride-induced hepatic injury groups [carbon tetrachloride for four (n=14), eight (n=8), or twelve (n=8) weeks] and the control group (n=10). Gd-EOB-DTPA-enhanced MRI was performed including T1-mapping (delayed to 50 min), DCE, and multiple hepatobiliary phases. Indocyanine green retention rate at 15 min (ICG-R15) was determined. Parameters such as T1 reduction rate (ΔT1), elimination half-life of ΔT1 (T_{ΔT1 1/2}), relative enhancement (RE), time to maximum RE (T_max), and perfusion parameters were calculated. Pearson correlation analysis was used for correlation analysis between ICG-R15 and each MRI indices.
Results ΔT1 at 30, 40, and 50 min showed significant positive correlations with ICG-R15 ( r=0.784, 0.653, 0.757, P=0.007, 0.041, 0.030). T_{ΔT1 1/2} showed a significant positive correlation with ICG-R15 (r=0.685, P=0.029). T_maxshowed a significant positive correlation with ICG-R15 (r=0.532, P=0.019).
Conclusions ΔT1 in the late hepatobiliary phase and T _{ΔT1 1/2} exhibited moderate correlations with liver function. The longer time period of Gd-EOB-DTPA-enhanced T1 mapping scanning, as well as DCE and multiple hepatobiliary phases, may be of some value for estimating liver function in rats with liver fibrosis.

Key words: liver function, T1 mapping, Gd-EOB-DTPA, magnetic resonance imaging

Jia Xu, Xuan Wang, Zhengyu Jin, Qin Wang, Yan You, Shitian Wang, Tianyi Qian, Huadan Xue. Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help[J].Chinese Medical Sciences Journal, 2021, 36(2): 110-119.

图/表 4

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