Chinese Medical Sciences Journal ›› 2018, Vol. 33 ›› Issue (3): 152-159.doi: 10.24920/11814

• 论著 • 上一篇    下一篇



  1. 航天中心医院检验科,北京 100049
  • 出版日期:2018-09-30 发布日期:2018-05-28
  • 通讯作者: 梁国威

Urinary Myeloperoxidase to Creatinine Ratio as a New Marker for Diagnosis of Urinary Tract Infection

Bai Mingjian,Feng Jing,Liang Guowei()   

  1. Department of Clinical Laboratory, Aerospace Central Hospital, Beijing 100049, China
  • Published:2018-09-30 Online:2018-05-28
  • Contact: Liang Guowei


目的 探讨尿髓过氧化物酶与肌酐比值(MCR)是否可作为泌尿系感染(UTI)诊断的指标。方法 将疑似UTI的患者根据尿培养结果分为培养阳性组和培养阴性组。并对两组患者尿液MCR、白细胞(WBC)和细菌进行检测和比较。结果 253例患者中有157例尿培养阳性,96例培养阴性。尿MCR、WBC和细菌分别以2为基数取对数。尿液培养阳性组和阴性组间log2MCR、log2WBC(定量)、log2bacteria、WBC(半定量)水平分别为 (8.6±2.5比5.4±1.5,t=-12.453,P=0.001)、(8.0±2.5比5.2±1.8,t=-10.332,P=0.001)、(11.4±2.5比8.2±2.8,t=-9.297,P=0.001)、[2(1,3)比1(0.5,1),Z=-7.580,P=0.001],差异均有统计学意义。在尿培养阳性组中,革兰阳性菌组与阴性菌组的log2MCR水平分别为7.2±2.5 和9.0±2.4,t=4.016,P=0.001,差异有统计学意义。log2MCR与log2WBC(定量)、log2bacteria、WBC(半定量)相关性(Pearson)分别为0.708(P=0.001)、0.381(P=0.001)、0.606 (P=0.001)。结论 MCR与WBC计数呈正相关,可作为诊断UTI新的标志物。MCR甚至可以用于初步推断UTI的细菌类型。

关键词: 尿液, 髓过氧化物酶, 诊断, 泌尿系感染


Objective To determine whether urinary myeloperoxidase to creatinine ratio (MCR) can serve as a marker for diagnosis of urinary tract infection (UTI).Methods Patients suspected of UTI were consecutively enrolled and further divided into the culture positive and the sterile groups according to urine culture results. Subsequently, MCR, white blood cell (WBC) and bacteria in the urinary samples from patients were detected and compared between the two groups.Results Finally, 253 patients were enrolled including 157 urine culture positive patients and 96 urine culture negative patients (sterile group). After logarithmic transformation in 2 as the base, the MCR, WBC, and bacteria were separately presented as log2 MCR, log2 WBC(quantitative) , and log2 bacteria. The values of log2 MCR(8.6±2.5 vs. 5.4±1.5, t=-12.453, P=0.001), log2 WBC(quantitative) (8.0±2.5 vs. 5.2±1.8, t=-10.332, P=0.001), log2 bacteria (11.4±2.5 vs. 8.2±2.8, t=-9.297, P=0.001) and WBC (semi-quantitative) [2 (interquartile range 1, 3) vs. 1 (interquartile range 0.5, 1), Z=-7.580, P=0.001] showed significant difference between the urine culture positive group and the sterile group. Among the urine culture positive group, the values of log2 MCR of the gram positive and gram negative subgroups were 7.2±2.5 and 9.0±2.4 (t=4.016, P=0.001), respectively. The correlation between log2 MCR and log2 WBC (quantitative), log2 bacteria, WBC (semi-quantitative) was 0.708 (Pearson correlation, P=0.001), 0.381 (Pearson correlation, P=0.001), and 0.606 (Spearman correlation, P=0.001), respectively. Conclusions MCR is positively correlated with WBC counts and could be served as a promising biomarker for diagnosis of UTI. MCR could be even used for initial inference of infectious bacteria types of UTI.

Key words: urine, myeloperoxidase, diagnosis, urinary tract infection

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