Chinese Medical Sciences Journal ›› 2020, Vol. 35 ›› Issue (4): 357-365.doi: 10.24920/003659

• Review • Previous Articles     Next Articles

Wnt5a Plays Controversial Roles in Cancer Progression

Xu Chen1, Hongling Liu2, Fenghui Zhao1, *(), Zongxian Jiao3, Jinsui Wang1, Yamei Dang1   

  1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
    2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
    3Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China
  • Received:2019-09-12 Accepted:2020-02-04 Published:2020-12-31 Online:2020-10-28
  • Contact: Fenghui Zhao

Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. Therefore, it is an essential factor in cancers’ progression (invasion, migration, proliferation, and epithelial-mesenchymal transition), and a potential biomarker for prognosis and treatment.

Key words: Wnt5a, cancer, methyl modification

Article information: 甘肃省卫生行业科研计划项目基金(项目编号:GSWSKY2018-34)

Funding: Gansu Health and Family Planning Commission Funding(GSWSKY2018-34)

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