Chinese Medical Sciences Journal ›› 2014, Vol. 29 ›› Issue (4): 197-203.doi: 10.1016/S1001-9294(14)60070-5

• ORIGINAL ARTICLE •     Next Articles

BRAF V600E Mutation as a Predictive Factor of Anti-EGFR Monoclonal Antibodies Therapeutic Effects in Metastatic Colorectal Cancer: a Meta-analysis

Qi Wang, Wei-guo Hu, Qi-bin Song*, Jia Wei   

  1. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Received:2014-04-09 Online:2014-11-28 Published:2014-11-28
  • About author:*Corresponding author Tel: 86-27-88041911, E-mail: qibinsong@163.com

Abstract: Objective To investigate the correlation between BRAF V600E mutation and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) therapeutic effects in metastatic colorectal cancer. Methods Studies were included into meta-analysis to investigate the association between BRAF V600E mutation and clinical outcome in metastatic colorectal cancer patients treated with anti-EGFR MoAbs. Results A total of 7 studies were included in this meta-analysis. The 7 studies included 1352 patients in total, sample sizes ranged from 67 to 493. Objective response rate (ORR), progression-free survival (PFS) and overall survival (OS) were collected from included studies and were used to assess the strength of the relation. In patients with wild-type KRAS, the pooled odds ratio for ORR of mutant BRAF over wild-type BRAF was 0.27 (95% CI=0.10-0.70). BRAF mutation predicted a deterioration in PFS and OS in wild-type KRAS patients treated with anti-EGFR MoAbs (hazard ratio=2.78, 95% CI=1.62-4.76; hazard ratio=2.54, 95% CI=1.93-3.32). Conclusion BRAF V600E mutation is related to lack of response and worse survival in wild-type KRAS metastatic colorectal cancer patients treated with anti-EGFR MoAbs.

Key words: colorectal neoplasms, meta-analysis

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